A three-dimensional culture model of innervated human skeletal muscle enables studies of the adult neuromuscular junction and disease modeling
M. Afshar Bakooshli, E. S. Lippmann, B. Mulcahy, N. Iyer, C. T. Nguyen, K. Tung, B. A. Stewart, H. van den Dorpel, T. Fuehrmann, M. S. Shoichet, A. Bigot, E. Pegoraro, H. Ahn, H. Ginsberg, M. Zhen, , P. M. Gilbert
This paper introduces a 3D co-culture model of human skeletal muscle and motor neurons to study adult neuromuscular junction development and disease, showing increased receptor upregulation and disease modeling capability.
bioRxiv · Nov 26, 2018 · PreprintBioengineering