C. T. Nguyen

Direct extrusion of multifascicle prevascularized human skeletal muscle for volumetric muscle loss surgery

This paper develops a method to create multifascicle human skeletal muscle scaffolds for volumetric muscle loss repair, showing that cocultured scaffolds regenerate muscle in vivo.

Soybean RIN4 represents a mechanistic link between plant immune and symbiotic signaling

This paper identifies RIN4 phosphorylation as a critical link between plant immune and symbiotic signaling in soybean, showing its necessity for nodulation and compatibility with rhizobia.

Electron microscopic analysis of the influence of iPSC-derived motor neurons on bioengineered human skeletal muscle tissues

The paper examines how iPSC-derived motor neurons affect the ultrastructure of bioengineered human skeletal muscle tissues, showing improved sarcomere organization with motor neuron co-culture.

Fc-modified SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models.

The paper develops Fc-modified SARS-CoV-2 neutralizing antibodies effective against variants, showing reduced viral titers and lung damage in animal models.

An attenuated vaccinia vaccine encoding the SARS-CoV-2 spike protein elicits broad and durable immune responses, and protects cynomolgus macaques and human ACE2 transgenic mice from SARS-CoV-2 and its variants

This study develops a vaccinia-based vaccine encoding SARS-CoV-2 spike protein that induces broad and durable immunity, protecting against multiple variants in non-human primates and transgenic mice.

Mechanodetection of neighbor plants elicits adaptive leaf movements through calcium dynamics

This study identifies a calcium-dependent signaling pathway in Arabidopsis that mediates touch-induced hyponasty, showing it is adaptive in plant competition.

Optimization of an LNP-mRNA vaccine candidate targeting SARS-CoV-2 receptor-binding domain

This study optimizes an LNP-mRNA vaccine targeting SARS-CoV-2 RBD by removing reactogenic materials, improving immunogenicity and protection in macaques.

Electrophysiological analysis of healthy and dystrophic 3D bioengineered skeletal muscle tissues

This study analyzes electrophysiological properties of healthy and dystrophic 3D bioengineered skeletal muscle tissues, showing DMD features are replicated in the model and a block co-polymer improves membrane potential.

Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques

This study examines immune responses in cynomolgus macaques infected with SARS-CoV-2, showing both neutralizing antibodies and IFN-γ-producing T-cells contribute to viral clearance.