The COVID-19 mRNA vaccine Comirnaty induces anaphylactic shock in an anti-PEG hyperimmune large animal model: Role of complement in cardiovascular, hematological, and inflammatory mediator changes
B. A. Barta, T. Radovits, A. B. Dobos, G. T. Kozma, T. Meszaros, P. Berenyi, R. Facsko, T. G. Fulop, B. Merkely, J. Szebeni
This study shows that anti-PEG antibodies cause anaphylactic shock in pigs after Comirnaty vaccination, with complement activation and TXA2 release contributing to the reaction.
bioRxiv · May 19, 2023 · PreprintPharmacology & Toxicology