J. Szebeni

mRNA-LNP COVID-19 vaccine lipids induce low level complement activation and production of proinflammatory cytokines: Mechanisms, effects of complement inhibitors, and relevance to adverse reactions

This study investigates how mRNA-LNP vaccines trigger complement activation and cytokine production, linking these processes to inflammatory adverse events and suggesting potential therapeutic strategies.

The COVID-19 mRNA vaccine Comirnaty induces anaphylactic shock in an anti-PEG hyperimmune large animal model: Role of complement in cardiovascular, hematological, and inflammatory mediator changes

This study shows that anti-PEG antibodies cause anaphylactic shock in pigs after Comirnaty vaccination, with complement activation and TXA2 release contributing to the reaction.

New insights into the structure of Comirnaty Covid-19 vaccine: A theory on soft nanoparticles with mRNA-lipid supercoils stabilized by hydrogen bonds

This paper investigates the nanoscale structure of Comirnaty mRNA-LNP vaccine using multiple imaging techniques, revealing a granular core stabilized by hydrogen bonds between mRNA and lipids.

Zymosan-induced leukocyte and cytokine changes in pigs: a new model for streamlined drug testing against severe COVID-19

This paper develops a pig model of zymosan-induced immune and hemodynamic changes that mimic late-stage COVID-19 symptoms, enabling drug testing for cytokine storm.