P. Berenyi

mRNA-LNP COVID-19 vaccine lipids induce low level complement activation and production of proinflammatory cytokines: Mechanisms, effects of complement inhibitors, and relevance to adverse reactions

This study investigates how mRNA-LNP vaccines trigger complement activation and cytokine production, linking these processes to inflammatory adverse events and suggesting potential therapeutic strategies.

The COVID-19 mRNA vaccine Comirnaty induces anaphylactic shock in an anti-PEG hyperimmune large animal model: Role of complement in cardiovascular, hematological, and inflammatory mediator changes

This study shows that anti-PEG antibodies cause anaphylactic shock in pigs after Comirnaty vaccination, with complement activation and TXA2 release contributing to the reaction.