Reversal of lactate and PD-1-mediated macrophage immunosuppression controls growth of PTEN/p53-deficient prostate cancer
K. Chaudagar, H. M. Hieromnimon, R. Khurana, B. Labadie, T. Heirz, S. Mei, R. Hasan, J. Shafran, A. Kelley, E. Apostolov, G. Al-Eryani, K. Harvey, S. Rameshbabu, M. Loyd, K. Bynoe, , A. Patnaik
The paper shows that inhibiting lactate production in tumor cells suppresses PTEN/p53-deficient prostate cancer growth by activating macrophage phagocytosis.
bioRxiv · May 12, 2022Cancer Biology