Author

J. Shafran

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Organism:human· 1

Frequent Co-Authors

A. Patnaik· 3 shared B. Labadie· 3 shared A. Kelley· 2 shared A. Solanki· 2 shared C. Drovetsky· 2 shared E. Markiewicz· 2 shared K. Bynoe· 2 shared K. K. Chaudagar· 2 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

A. Patnaik

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Author profile →

3 papers

Recent·Most cited

Androgen blockade primes NLRP3 in macrophages to induce tumor phagocytosis

K. K. Chaudagar, R. Srikrishnan, S. Mei, T. Hirz, Y.-M. Hu, A. Argulian, B. Labadie, K. Desai, S. Grimaldo, D. Kahramangil, R. Nair, S. D Souza, D. Zhou, M. Li, F. Doughan, , A. Patnaik

This study shows that androgen blockade increases NLRP3 in macrophages, which when combined with NLRP3 agonist, enhances cancer cell phagocytosis and tumor control in a mouse model of prostate cancer.

bioRxiv · Sep 15, 2023 · PreprintCancer Biology

Suppression of tumor cell lactate-generating signaling pathways eradicates murine PTEN/p53-deficient aggressive-variant prostate cancer via macrophage phagocytosis

K. K. Chaudagar, H. Hieromnimon, A. Kelley, B. Labadie, J. Shafran, S. Rameshbabu, C. Drovetsky, K. Bynoe, A. Solanki, E. Markiewicz, X. Fan, M. Loda, A. Patnaik

This study shows that blocking lactate-producing pathways in PTEN/p53-deficient prostate cancer enhances macrophage phagocytosis, leading to durable tumor control in mice.

bioRxiv · May 23, 2023Cancer Biology

Reversal of lactate and PD-1-mediated macrophage immunosuppression controls growth of PTEN/p53-deficient prostate cancer

K. Chaudagar, H. M. Hieromnimon, R. Khurana, B. Labadie, T. Heirz, S. Mei, R. Hasan, J. Shafran, A. Kelley, E. Apostolov, G. Al-Eryani, K. Harvey, S. Rameshbabu, M. Loyd, K. Bynoe, , A. Patnaik

The paper shows that inhibiting lactate production in tumor cells suppresses PTEN/p53-deficient prostate cancer growth by activating macrophage phagocytosis.

bioRxiv · May 12, 2022Cancer Biology