Author

K. Bynoe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Patnaik· 3 shared A. Solanki· 3 shared A. Kelley· 2 shared B. Labadie· 2 shared C. Drovetsky· 2 shared E. Markiewicz· 2 shared H. M. Hieromnimon· 2 shared J. Shafran· 2 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

A. Patnaik

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Suppression of tumor cell lactate-generating signaling pathways eradicates murine PTEN/p53-deficient aggressive-variant prostate cancer via macrophage phagocytosis

K. K. Chaudagar, H. Hieromnimon, A. Kelley, B. Labadie, J. Shafran, S. Rameshbabu, C. Drovetsky, K. Bynoe, A. Solanki, E. Markiewicz, X. Fan, M. Loda, A. Patnaik

This study shows that blocking lactate-producing pathways in PTEN/p53-deficient prostate cancer enhances macrophage phagocytosis, leading to durable tumor control in mice.

bioRxiv · May 23, 2023Cancer Biology

Reversal of lactate and PD-1-mediated macrophage immunosuppression controls growth of PTEN/p53-deficient prostate cancer

K. Chaudagar, H. M. Hieromnimon, R. Khurana, B. Labadie, T. Heirz, S. Mei, R. Hasan, J. Shafran, A. Kelley, E. Apostolov, G. Al-Eryani, K. Harvey, S. Rameshbabu, M. Loyd, K. Bynoe, , A. Patnaik

The paper shows that inhibiting lactate production in tumor cells suppresses PTEN/p53-deficient prostate cancer growth by activating macrophage phagocytosis.

bioRxiv · May 12, 2022Cancer Biology

Cabozantinib unlocks efficient in vivo targeted delivery of neutrophil-loaded nanoparticles into murine prostate tumors

K. Chaudagar, N. Landon-Brace, A. Solanki, H. M. Hieromnimon, E. Hegermiller, W. Li, Y. Shao, D. Wilkins, K. Bynoe, X.-L. Li, J. Clohessy, S. Ullas, J. Karp, A. Patnaik

This study shows cabozantinib enhances neutrophil-mediated delivery of nanoparticles to prostate tumors in mice, leading to higher NP accumulation in the tumor microenvironment.

bioRxiv · Apr 13, 2020Cancer Biology