Author

T. Hempel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Approach:contrastive learning· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

F. Noe· 4 shared A. M. Klingler· 1 shared A. Mardt· 1 shared B. C. Taylor· 1 shared C. Clementi· 1 shared C. T. Lee· 1 shared L. Raich· 1 shared M. E. Rothenberg· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersBiophysics

F. Noe

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Author profile →

4 papers

Recent·Most cited

Deep learning to decompose macromolecules into independent Markovian domains

A. Mardt, T. Hempel, C. Clementi, F. Noe

This paper introduces a method combining independent Markov decomposition with VAMPnets to decompose large molecular systems into Markovian subdomains, improving data efficiency and interpretability.

bioRxiv · Mar 30, 2022Biophysics

Independent Markov Decomposition: Towards modeling kinetics of biomolecular complexes

T. Hempel, M. J. del Razo, C. T. Lee, B. C. Taylor, R. E. Amaro, F. Noe

This paper introduces Independent Markov Decomposition (IMD) to model kinetics of biomolecular complexes by decomposing systems into weakly coupled subsystems, reducing sampling requirements while preserving accuracy.

bioRxiv · Mar 24, 2021Biophysics

Molecular mechanism of SARS-CoV-2 cell entry inhibition via TMPRSS2 by Camostat and Nafamostat mesylate

T. Hempel, L. Raich, S. Olsson, N. P. Azouz, A. M. Klingler, M. E. Rothenberg, F. Noe

This study investigates how camostat and nafamostat inhibit SARS-CoV-2 entry by targeting TMPRSS2 through molecular simulations and experiments, showing nafamostat's higher efficacy due to increased Michaelis complex binding.

Chemical Science · Jan 1, 2021Peer-reviewedBiophysics

Coupling of conformational switches in calcium sensor unraveled with local Markov models and transfer entropy

T. Hempel, N. Plattner, F. Noe

The paper uses molecular dynamics and Markov models to analyze conformational coupling in the C2A domain of Synaptotagmin-1, revealing how calcium binding influences domain switching.

bioRxiv · Feb 25, 2020Biophysics