Author

C. T. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 6 Bioengineering· 1 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 5 Approach:deep learning· 3 Research Focus:protein folding & dynamics· 3 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:software / tool· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

P. Rangamani· 4 shared R. E. Amaro· 4 shared B. C. Taylor· 3 shared A. Mahapatra· 1 shared A. Sangani· 1 shared B. R. Jagger· 1 shared C. Chen· 1 shared C. Zhu· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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4 shared papersBiophysics

P. Rangamani

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Author profile →

8 papers

Recent·Most cited

Improved Activity and Kinetics of Endoglucanase Biofuel Enzyme with Addition of an AzoTAB Surfactant

Z. P. Seidel, C. T. Lee

This study shows that adding azoTAB surfactant enhances endoglucanase activity and kinetics, particularly under UV light, leading to improved enzyme efficiency and substrate conversion.

bioRxiv · Aug 20, 2023 · PreprintBioengineering

Cristae formation is a mechanical buckling event controlled by the inner membrane lipidome

K. Venkatraman, C. T. Lee, G. C. Garcia, A. Mahapatra, D. Milshteyn, G. Perkins, K.-Y. Kim, H. A. Pasolli, S. Phan, J. Lippincott-Schwartz, M. Ellisman, P. Rangamani, I. Budin

The paper shows that cardiolipin buffers mitochondrial inner membrane curvature and ATP synthase organization, with a mathematical model predicting snapthrough instability in cristae formation.

bioRxiv · Mar 13, 2023 · PreprintBiophysics

The ins and outs of membrane bending by intrinsically disordered proteins

F. Yuan, C. T. Lee, A. Sangani, J. Houser, L. Wang, E. Lafer, P. Rangamani, J. Stachowiak

This study investigates how intrinsically disordered proteins with both repulsive and attractive domains influence membrane curvature based on domain positioning and ionic strength.

bioRxiv · Dec 17, 2022Biophysics

Mem3DG: Modeling Membrane Mechanochemical Dynamics in 3D using Discrete Differential Geometry

C. Zhu, C. T. Lee, P. Rangamani

This paper introduces Mem3DG, a framework for modeling 3D membrane mechanochemical dynamics using discrete differential geometry, demonstrating its ability to simulate complex shape transformations and integrate additional physical phenomena.

bioRxiv · Oct 30, 2021Biophysics

Independent Markov Decomposition: Towards modeling kinetics of biomolecular complexes

T. Hempel, M. J. del Razo, C. T. Lee, B. C. Taylor, R. E. Amaro, F. Noe

This paper introduces Independent Markov Decomposition (IMD) to model kinetics of biomolecular complexes by decomposing systems into weakly coupled subsystems, reducing sampling requirements while preserving accuracy.

bioRxiv · Mar 24, 2021Biophysics

Benchmarking ensemble docking methods as a scientific outreach project

J. L. Gan, D. Kumar, C. Chen, B. C. Taylor, B. R. Jagger, R. E. Amaro, C. T. Lee

High school students benchmarked ensemble docking methods for ligand affinity prediction in a drug discovery challenge, finding Cathepsin S challenging and exploring advanced techniques.

bioRxiv · Oct 2, 2020 · PreprintScientific Communication & Education

An Open Source Mesh Generation Platform for Biophysical Modeling Using Realistic Cellular Geometries

C. T. Lee, J. G. Laughlin, J. B. Moody, R. E. Amaro, J. A. McCammon, M. J. Holst, P. Rangamani

The paper introduces GAMer 2, a mesh generation tool for converting structural biology data into geometric meshes suitable for biophysical modeling.

bioRxiv · Dec 17, 2019Biophysics

Structural basis for ligand modulation of the CCR2 conformational landscape

B. C. Taylor, C. T. Lee, R. E. Amaro

This study investigates how orthosteric and allosteric antagonists affect CCR2 dynamics using molecular dynamics simulations and Markov-state models, revealing stable inactive conformations and potential drug binding sites.

bioRxiv · Aug 14, 2018Biophysics