Author

T. Isermann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

R. Schulz-Heddergott· 2 shared U. M. Moll· 2 shared A. Stender· 1 shared B. Mundt· 1 shared B. Papke· 1 shared F. Feuerhake· 1 shared F. Kuehnel· 1 shared F. Wegwitz· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

R. Schulz-Heddergott

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Enhancement of colorectal cancer therapy through interruption of the HSF1-HSP90 axis by p53 activation or cell cycle inhibition

T. Isermann, K. L. Schneider, F. Wegwitz, T. De Oliveira, L.-C. Conradi, V. Volk, F. Feuerhake, B. Papke, S. Stintzing, B. Mundt, F. Kuehnel, U. M. Moll, R. Schulz-Heddergott

This study shows that combining HSP90 inhibitors with p53 activation or CDK4/6 inhibition enhances colorectal cancer therapy by disrupting the HSF1-HSR feedback loop.

bioRxiv · Feb 22, 2024Cancer Biology

Suppression of HSF1 activity by wildtype p53 creates the driving force for p53 loss-of-heterozygosity, enabling mutant p53 stabilization and invasion

O. C. Sener, A. Stender, L. Klemke, N. Stark, T. Isermann, J. Li, U. M. Moll, R. Schulz-Heddergott

This paper identifies the WTp53-HSF1 axis as the driver of p53LOH in colorectal tumors, enabling mutp53 stabilization and invasion.

bioRxiv · Apr 23, 2020Cancer Biology