T. de Oliveira

Enhancement of colorectal cancer therapy through interruption of the HSF1-HSP90 axis by p53 activation or cell cycle inhibition

This study shows that combining HSP90 inhibitors with p53 activation or CDK4/6 inhibition enhances colorectal cancer therapy by disrupting the HSF1-HSR feedback loop.

Selection analysis identifies unusual clustered mutational changes in Omicron lineage BA.1 that likely impact Spike function

The paper identifies 13 rare mutations in the Omicron S-gene that cluster in functionally important regions and likely impact Spike function, suggesting cooperative interactions that mitigate fitness costs.

SARS-CoV-2 cell-to-cell spread occurs rapidly and is insensitive to antibody neutralization

This study shows SARS-CoV-2 spreads rapidly between cells via fusion and is resistant to antibody neutralization, unlike cell-free virus.

Naturally-acquired immunity in Syrian Golden Hamsters provides protection from re-exposure to emerging heterosubtypic SARS-CoV-2 variants B.1.1.7 and B.1.351

This study shows that prior SARS-CoV-2 infection in Syrian Golden Hamsters protects against re-exposure to variants B.1.1.7 and B.1.351, suggesting immunity may limit disease from emerging variants.

SARS-CoV-2 501Y.V2 (B.1.351) elicits cross-reactive neutralizing antibodies

This study examines antibody responses to the SARS-CoV-2 501Y.V2 variant in patients hospitalized in early 2021, finding robust cross-reactivity against earlier variants and the 501Y.V3 variant.

Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains

This study compares antibody cross-reactivity between SARS-CoV-2 B.1.1.7 and parental strains, finding reduced recognition and neutralization of older variants after B.1.1.7 infection.

SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma

This study shows that SARS-CoV-2 501Y.V2 pseudovirus escapes neutralization by South African convalescent plasma but not binding, suggesting potential for reinfection and reduced vaccine efficacy.

HIV cell-to-cell spread slows evolution of drug resistance

This study shows that HIV cell-free infection accelerates the evolution of drug resistance compared to cell-to-cell spread, with cell-free infection enabling multidrug resistance in the presence of two reverse transcriptase inhibitors.

Complementation can maintain a quasispecies of drug sensitive and resistant HIV

The paper shows that complementation between drug-sensitive and resistant HIV genotypes maintains a stable quasispecies, preventing the resistant genotype from outcompeting the sensitive one.

Yellow fever virus spread in Rio de Janeiro and Espirito Santo, 2016-2019: Phylodynamic assessment to improve intervention strategies

This study uses genomic sequencing of yellow fever virus from 2016-2019 to trace transmission routes and improve public health responses in Brazil.

The CNS in the face of ART contains T cell origin HIV which can lead to drug resistance

The paper investigates the origin of HIV in the CNS of ART-suppressed individuals and finds T cell-derived HIV that can lead to drug resistance.

Boosting Felsenstein Phylogenetic Bootstrap

The paper revises Felsensteins bootstrap method to improve support values for deep branches in large phylogenies without creating false supports.