Author

T. J. Kirby

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

J. Lammerding· 3 shared L. L. Wallrath· 2 shared A. J. Earle· 1 shared A. M. Gacita· 1 shared C. D. Morsink· 1 shared E. H. H. Fong· 1 shared E. McNally· 1 shared G. Bonne· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCell Biology

J. Lammerding

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3 papers

Recent·Most cited

Eliminating elevated p53 signaling fails to rescue skeletal muscle defects or extend survival in Lamin A/C-deficient mice.

T. J. Kirby, H. C. Zahr, E. H. H. Fong, J. Lammerding

This study investigates whether reducing p53 activation can alleviate skeletal muscle defects in Lamin A/C-deficient mice, but finds no improvement in disease phenotype or survival.

bioRxiv · Jul 8, 2022Cell Biology

Nuclear damage in LMNA mutant iPSC-derived cardiomyocytes is associated with impaired lamin localization to the nuclear envelope

M. Wallace, H. Zahr, S. Perati, C. D. Morsink, L. E. Johnson, A. M. Gacita, S. Lai, L. L. Wallrath, I. J. Benjamin, E. McNally, T. J. Kirby, J. Lammerding

This study shows that LMNA mutations in iPSC-derived cardiomyocytes cause nuclear shape changes, reduced stiffness, and lamin mislocalization, linking nuclear abnormalities to LMNA-DCM pathogenesis.

bioRxiv · Oct 30, 2021 · PreprintCell Biology

Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells

A. J. Earle, T. J. Kirby, G. R. Fedorchak, P. Isermann, J. Patel, S. Iruvanti, S. A. Moore, G. Bonne, L. L. Wallrath, J. Lammerding

This study shows that LMNA mutations cause nuclear envelope rupture and DNA damage in muscle cells, leading to disease through mechanical stress and DNA damage pathways.

bioRxiv · Aug 17, 2019Cell Biology