Author

D. H. Mathews

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1

Frequent Co-Authors

A. M. Keedakkatt Puthenpeedikakkal· 1 shared C. Cavender· 1 shared C. L. Kielkopf· 1 shared C. S. Anderson· 1 shared D. H. Turner· 1 shared D. Maji· 1 shared D. N. Ermolenko· 1 shared E. Farah· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperBiophysics

A. M. Keedakkatt Puthenpeedikakkal

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Generation and functional analysis of defective viral genomes during SARS-CoV-2 infection

T. Zhou, N. J. Gilliam, S. Li, S. Spaudau, R. Osborn, C. S. Anderson, T. J. Mariani, J. Thakar, S. Dewhurst, D. H. Mathews, L. Huang, Y. Sun

This study identifies DVG generation in SARS-CoV-2 and links it to IFN stimulation and persistent infection, showing higher DVG levels in symptomatic patients.

bioRxiv · Sep 22, 2022Microbiology

RNA Helix Thermodynamics: The End Game

J. Zuber, S. J. Schroeder, H. Sun, D. H. Turner, D. H. Mathews

The paper updates RNA helix thermodynamic parameters by incorporating sequence-dependent terminal penalties, improving prediction accuracy for helix stability.

bioRxiv · Oct 16, 2021Biophysics

Pre-mRNA Splicing Factor U2AF2 Recognizes Distinct Conformations of Nucleotide Variants at the Center of the pre-mRNA Splice Site Signal

E. Glasser, D. Maji, G. Biancon, A. M. Keedakkatt Puthenpeedikakkal, C. Cavender, T. Tebaldi, M. J. Pulvino, J. L. Jenkins, D. H. Mathews, S. Halene, C. L. Kielkopf

This study investigates how U2AF2 recognizes different nucleotides at the center of the Py tract in pre-mRNA splice sites using structural and functional analyses.

bioRxiv · Sep 27, 2021Biophysics

The formation of intramolecular secondary structure brings mRNA ends in close proximity

W.-J. C. Lai, M. Kayedkhordeh, E. V. Cornell, E. Farah, S. Bellaousov, R. Rietmeijer, D. H. Mathews, D. N. Ermolenko

The paper shows that mRNAs from various organisms, including humans, inherently fold into structures bringing their ends within 7 nm, regardless of length, except for specific unstructured sequences.

bioRxiv · Mar 27, 2018Biochemistry