Dmp1Cre-directed knockdown of PTHrP in murine decidua is associated with increased bone width and a life-long increase in strength specific to male progeny
N. Ansari, T. Isojima, B. Crimeen-Irwin, I. J. Poulton, N. E. McGregor, P. M. Ho, C. S. Kovacs, E. Dimitriadis, J. H. Gooi, T. J. Martin, N. A. Sims
The paper shows that knocking down PTHrP in murine decidua via Dmp1Cre leads to increased bone width and strength in male offspring, suggesting a maternal influence on bone development.
bioRxiv · Jun 9, 2020Cell Biology