N. A. Sims

Enrichable consortia of microbial symbionts degrade macroalgal polysaccharides in Kyphosus fish

This study identifies microbial symbionts in Kyphosus fish that collaboratively degrade macroalgal polysaccharides through genomic analysis and suggests their potential for industrial applications.

Rothmund-Thomson Syndrome-like RECQL4 truncating mutations cause a haploinsufficient low bone mass phenotype in mice

This study shows that truncating RECQL4 mutations in mice cause low bone mass and reduced cortical bone thickness, highlighting RECQL4 gene dosage as a regulator of bone mass.

Dmp1Cre-directed knockdown of PTHrP in murine decidua is associated with increased bone width and a life-long increase in strength specific to male progeny

The paper shows that knocking down PTHrP in murine decidua via Dmp1Cre leads to increased bone width and strength in male offspring, suggesting a maternal influence on bone development.

Increased autophagy in ephrinB2 deficient osteocytes is associated with hypermineralized, brittle bones

This study shows that ephrinB2 deficiency in osteocytes increases autophagy, leading to accelerated secondary mineralization and brittle bones.

Effects of Parathyroid Hormone, Alendronate and Odanacatib on the mineralisation process in intracortical and endocortical Haversian boneof ovariectomized rabbits

This study compares the effects of parathyroid hormone, alendronate, and odanacatib on bone mineralization in cortical bone of ovariectomized rabbits, finding differences in bone formation and matrix maturation.