Author

T. J. Mulhern

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:organoid / primary culture· 1

Frequent Co-Authors

A. L. Gard· 3 shared C. R. Fisher· 3 shared J. T. Borenstein· 3 shared R. J. Luu· 3 shared E. P. Gabriel· 2 shared F. M. Medie· 2 shared L. D. Rubio· 2 shared B. Medoff· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersBioengineering

A. L. Gard

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Author profile →

3 papers

Recent·Most cited

A human primary airway microphysiological system infected with SARS-CoV-2 distinguishes the treatment efficacy between nirmatrelvir and repurposed compounds fluvoxamine and amodiaquine

L. Lopez Quezada, F. Mba Medie, E. P. Gabriel, R. J. Luu, L. D. Rubio, T. J. Mulhern, J. T. Borenstein, C. R. Fisher, A. L. Gard

This study evaluates the antiviral efficacy of nirmatrelvir and repurposed drugs against SARS-CoV-2 using a human airway microphysiological system, showing discrepancies with prior in vitro results.

bioRxiv · Jun 27, 2023 · PreprintBioengineering

Predicting clinical outcomes of SARS-CoV-2 drug treatments with a high throughput human airway on chip platform

C. R. Fisher, F. M. Medie, R. J. Luu, L. L. Quezada, R. B. Gaibler, T. J. Mulhern, L. D. Rubio, E. E. Marr, E. P. Gabriel, J. T. Borenstein, A. L. Gard

The paper demonstrates that the PREDICT96-ALI platform can predict clinical outcomes of SARS-CoV-2 drug treatments by testing antiviral efficacy in a human airway on chip model.

bioRxiv · Jun 7, 2022 · PreprintMicrobiology

SARS-CoV-2 Viral Replication in a High Throughput Human Primary Epithelial Airway Organ Model

C. R. Fisher, F. M. Medie, R. J. Luu, R. Gaibler, C. R. Miller, T. J. Mulhern, V. Vijayakumar, E. Marr, J. Alladina, B. Medoff, J. T. Borenstein, A. L. Gard

This paper demonstrates SARS-CoV-2 infection and replication in a human primary airway epithelial organ-on-chip model, providing a new platform for disease modeling and drug screening.

bioRxiv · Jun 15, 2021 · PreprintBioengineering