R. J. Luu

A human primary airway microphysiological system infected with SARS-CoV-2 distinguishes the treatment efficacy between nirmatrelvir and repurposed compounds fluvoxamine and amodiaquine

This study evaluates the antiviral efficacy of nirmatrelvir and repurposed drugs against SARS-CoV-2 using a human airway microphysiological system, showing discrepancies with prior in vitro results.

Predicting clinical outcomes of SARS-CoV-2 drug treatments with a high throughput human airway on chip platform

The paper demonstrates that the PREDICT96-ALI platform can predict clinical outcomes of SARS-CoV-2 drug treatments by testing antiviral efficacy in a human airway on chip model.

SARS-CoV-2 Viral Replication in a High Throughput Human Primary Epithelial Airway Organ Model

This paper demonstrates SARS-CoV-2 infection and replication in a human primary airway epithelial organ-on-chip model, providing a new platform for disease modeling and drug screening.

High-Throughput Human Primary Cell-Based Airway Model for Evaluating Influenza, Coronavirus, or other Respiratory Viruses in vitro

This paper introduces a human primary airway epithelial cell-based model for evaluating influenza and coronavirus infections in vitro, demonstrating its ability to assess viral infection kinetics and therapeutic efficacy.