C. R. Fisher

A human primary airway microphysiological system infected with SARS-CoV-2 distinguishes the treatment efficacy between nirmatrelvir and repurposed compounds fluvoxamine and amodiaquine

This study evaluates the antiviral efficacy of nirmatrelvir and repurposed drugs against SARS-CoV-2 using a human airway microphysiological system, showing discrepancies with prior in vitro results.

Discovery of deep-sea coral symbionts from a novel family of marine bacteria, Oceanoplasmataceae, with severely reduced genomes

The paper identifies two deep-sea coral symbionts from a new bacterial family, Oceanoplasmataceae, with reduced genomes and unique energy acquisition strategies.

Predicting clinical outcomes of SARS-CoV-2 drug treatments with a high throughput human airway on chip platform

The paper demonstrates that the PREDICT96-ALI platform can predict clinical outcomes of SARS-CoV-2 drug treatments by testing antiviral efficacy in a human airway on chip model.

SARS-CoV-2 Viral Replication in a High Throughput Human Primary Epithelial Airway Organ Model

This paper demonstrates SARS-CoV-2 infection and replication in a human primary airway epithelial organ-on-chip model, providing a new platform for disease modeling and drug screening.

Deep-sea corals near cold seeps associate with chemoautotrophic bacteria that are related to the symbionts of cold seep and hydrothermal vent mussels.

The paper identifies SUP05 chemoautotrophic bacteria associated with deep-sea corals near cold seeps, suggesting a novel symbiotic relationship between corals and chemoautotrophic microbes.

T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein

The paper investigates how T-dependent B cells produce antibodies that form a high-avidity multivalent complex with Plasmodium falciparum CSP, revealing structural and immunological insights.