Recognition of Z-RNA by ADAR1 limits interferon responses
Q. Tang, R. E. Rigby, G. R. Young, A. Korning-Hvidt, T. K. Tang, A. Bridgeman, A. R. Townsend, G. Kassiotis, J. Rehwinkel
This study shows that ADAR1's Z domain prevents IFN responses by recognizing Z-RNA, and its absence leads to spontaneous IFN induction and improved viral control.
bioRxiv · Dec 4, 2020 · PreprintImmunology