Author

A. R. Townsend

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Research Focus:drug response / drug discovery· 4 Research Focus:differential expression· 2 Organism:mouse· 2 Organism:plant (other)· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

P. Rijal· 3 shared T. K. Tan· 3 shared A. A. Cohen· 2 shared A. McNee· 2 shared B. Paudyal· 2 shared E. Tchilian· 2 shared J. W. McCauley· 2 shared P. J. Bjorkman· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersImmunology

P. Rijal

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A locally administered single cycle influenza vaccine expressing a non-fusogenic stabilised haemagglutinin stimulates strong T-cell and neutralising antibody immunity

H. Sadler, P. Rijal, T. K. Tan, A. R. Townsend

This paper develops a single-cycle influenza vaccine, CLEARFLU, that induces neutralising antibodies to haemagglutinin and T-cell responses, offering broad and strain-specific protection.

bioRxiv · Mar 1, 2024 · PreprintImmunology

Multiviral Quartet Nanocages Elicit Broad Anti-Coronavirus Responses for Proactive Vaccinology

R. A. Hills, T. K. Tan, A. A. Cohen, J. R. Keefe, A. H. Keeble, P. N. Gnanapragasam, K. N. Storm, M. L. Hill, S. Liu, J. Gilbert-Jaramillo, M. Afzal, A. Napier, W. S. James, P. J. Bjorkman, A. R. Townsend, M. Howarth

A vaccine candidate with polyprotein antigens displayed on nanocages induces neutralizing antibodies to multiple SARS-like coronaviruses.

bioRxiv · Feb 24, 2023 · PreprintImmunology

Mosaic RBD nanoparticles protect against multiple sarbecovirus challenges in animal models

A. A. Cohen, N. A. van Doremalen, A. J. Greaney, H. Andersen, A. Sharma, T. N. Starr, J. R. Keeffe, C. Fan, J. E. Schulz, P. N. P. Gnanapragasam, L. M. Kakutani, A. P. West, G. Saturday, Y. E. Lee, H. Gao, , P. J. Bjorkman

This study designs mosaic RBD nanoparticles to elicit antibodies against conserved sarbecovirus epitopes, showing broader protection against SARS-CoV-2 variants and animal sarbecoviruses in animal models.

bioRxiv · Mar 25, 2022 · PreprintMicrobiology

Low dose pig anti-influenza virus monoclonal antibodies reduce lung pathology but do not prevent virus shedding

B. Paudyal, A. McNee, P. Rijal, B. V. Carr, A. Nunez, J. W. McCauley, R. S. Daniels, A. R. Townsend, J. A. Hammond, E. Tchilian

This study shows that high-dose pig monoclonal antibodies reduce lung pathology and virus load but not nasal shedding, suggesting lower doses may suffice for disease severity reduction.

bioRxiv · Oct 8, 2021Immunology

Recognition of Z-RNA by ADAR1 limits interferon responses

Q. Tang, R. E. Rigby, G. R. Young, A. Korning-Hvidt, T. K. Tang, A. Bridgeman, A. R. Townsend, G. Kassiotis, J. Rehwinkel

This study shows that ADAR1's Z domain prevents IFN responses by recognizing Z-RNA, and its absence leads to spontaneous IFN induction and improved viral control.

bioRxiv · Dec 4, 2020 · PreprintImmunology

Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans

B. Holzer, P. Rijal, A. McNee, B. Paudyal, B. Clark, T. Manjegowda, F. J. Salguero, E. Bessell, J. C. Schwartz, K. Moffat, M. Pedrera, S. P. Graham, M. B.-D. Placido, R. M. La Ragione, W. Mwangi, , E. Tchilian

This study generates pig-specific monoclonal antibodies against H1N1pdm09 influenza virus that target human-like HA epitopes and reduce disease severity in pigs.

bioRxiv · Jul 21, 2020Immunology