Author

R. E. Rigby

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

J. Rehwinkel· 4 shared A. Bridgeman· 2 shared C. Cursi· 2 shared T. Davenne· 2 shared A. Chabes· 1 shared A. Korning-Hvidt· 1 shared A. R. Townsend· 1 shared A. Schuh· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersImmunology

J. Rehwinkel

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4 papers

Recent·Most cited

Single-cell analysis of signalling and transcriptional responses to type I interferons

R. E. Rigby, K. Rue-Albrecht, D. Sims, J. Rehwinkel

This study examines how different type I interferons affect signaling and gene expression in human immune cells, finding that responses vary in magnitude but not qualitatively.

bioRxiv · Jul 3, 2023Immunology

Recognition of Z-RNA by ADAR1 limits interferon responses

Q. Tang, R. E. Rigby, G. R. Young, A. Korning-Hvidt, T. K. Tang, A. Bridgeman, A. R. Townsend, G. Kassiotis, J. Rehwinkel

This study shows that ADAR1's Z domain prevents IFN responses by recognizing Z-RNA, and its absence leads to spontaneous IFN induction and improved viral control.

bioRxiv · Dec 4, 2020 · PreprintImmunology

SAMHD1 limits the efficacy of forodesine in leukaemia by protecting cells against cytotoxicity of dGTP

T. Davenne, J. Klintman, S. Sharma, R. E. Rigby, C. Cursi, A. Bridgeman, B. Dadonaite, K. De Keersmaecker, P. Hillmen, A. Chabes, A. Schuh, J. Rehwinkel

This paper shows that SAMHD1 protects cells from dGTP toxicity caused by forodesine, and that forodesine can selectively kill SAMHD1-deficient leukemia cells.

bioRxiv · Feb 17, 2020Cancer Biology

Varicella-Zoster Virus ORF9 Is an Antagonist of the DNA Sensor cGAS

J. Hertzog, W. Zhou, R. E. Rigby, G. Fowler, C. Cursi, L. Chauveau, T. Davenne, P. J. Kranzusch, J. Rehwinkel

This study identifies ORF9 as a VZV protein that inhibits the cGAS/STING pathway, reducing type I IFN production during infection.

bioRxiv · Feb 11, 2020Immunology