Author

G. R. Young

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Evolutionary Biology· 2 Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

J. P. Stoye· 3 shared M. W. Yap· 2 shared R. Harvey· 2 shared A. Bridgeman· 1 shared A. Guedan· 1 shared A. Korning-Hvidt· 1 shared A. R. Townsend· 1 shared A. S. Fowler· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersEvolutionary Biology

J. P. Stoye

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Emergence of new subgenomic mRNAs in SARS-CoV-2

H. V. Mears, G. R. Young, T. Sanderson, R. Harvey, M. Crawford, D. M. Snell, A. S. Fowler, S. Hussain, J. Nicod, T. P. Peacock, E. Emmott, K. Finsterbusch, J. Luptak, E. Wall, B. Williams, , D. L. Bauer

This study identifies new subgenomic mRNAs in SARS-CoV-2 arising from mutations that create novel transcription regulatory sequences, leading to the expression of functional proteins like N.iORF3.

bioRxiv · Apr 20, 2022 · PreprintMicrobiology

SARS-CoV-2 ORF6 disrupts innate immune signalling by inhibiting cellular mRNA export

R. Hall, A. Guedan, M. W. Yap, G. R. Young, R. Harvey, J. P. Stoye, K. N. Bishop

This paper shows that SARS-CoV-2 ORF6 inhibits mRNA export by interacting with Rae1, suppressing antiviral responses and aiding viral replication.

bioRxiv · Feb 8, 2022Microbiology

Recognition of Z-RNA by ADAR1 limits interferon responses

Q. Tang, R. E. Rigby, G. R. Young, A. Korning-Hvidt, T. K. Tang, A. Bridgeman, A. R. Townsend, G. Kassiotis, J. Rehwinkel

This study shows that ADAR1's Z domain prevents IFN responses by recognizing Z-RNA, and its absence leads to spontaneous IFN induction and improved viral control.

bioRxiv · Dec 4, 2020 · PreprintImmunology

Duplication and divergence of the retrovirus restriction gene Fv1 in Mus caroli mice allows protection from multiple retroviruses

M. W. Yap, G. R. Young, R. Varnaite, S. Morand, J. P. Stoye

The paper identifies a duplicated Fv1 gene in Mus caroli mice that provides resistance to multiple retroviruses, suggesting evolutionary pressure from diverse viral threats.

bioRxiv · Oct 11, 2019Evolutionary Biology

Structure of D. melanogaster ARC1 reveals a repurposed molecule with characteristics of retroviral Gag

M. A. Cottee, S. C. Letham, G. R. Young, J. P. Stoye, I. A. Taylor

The paper presents the crystal structure of dARC1 and compares it to mammalian ARC and retroviral CA proteins, showing structural divergence and functional adaptation.

bioRxiv · Jul 10, 2019Evolutionary Biology