J. Rehwinkel

Iron deficiency causes aspartate-sensitive metabolic and proliferative dysfunction in CD8+ T cells

This study shows iron deficiency impairs CD8+ T cell proliferation and metabolism by disrupting mitochondrial function, but exogenous aspartate can rescue this defect.

Single-cell analysis of signalling and transcriptional responses to type I interferons

This study examines how different type I interferons affect signaling and gene expression in human immune cells, finding that responses vary in magnitude but not qualitatively.

The interferon-inducible GTPase MxB promotes capsid disassembly and genome release of herpesviruses

This study identifies MxB as an interferon-inducible GTPase that disassembles herpesvirus capsids, promoting genome release and enhancing innate immune responses.

ZBP1 induces inflammatory signaling via RIPK3 and promotes SARS-CoV-2-induced cytokine expression

This study identifies a ZBP1-RIPK1-RIPK3 pathway that promotes SARS-CoV-2-induced cytokine expression through inflammatory signaling independent of cell death.

The RNA sensor MDA5 detects SARS-CoV-2 infection

The paper identifies MDA5 as a cellular sensor for SARS-CoV-2 infection that induces type I and III interferons in Calu-3 cells.

Recognition of Z-RNA by ADAR1 limits interferon responses

This study shows that ADAR1's Z domain prevents IFN responses by recognizing Z-RNA, and its absence leads to spontaneous IFN induction and improved viral control.

Hypoxia regulates endogenous double-stranded RNA production via reduced mitochondrial DNA transcription

The paper shows hypoxia reduces mitochondrial double-stranded RNA production in breast cancer cells, leading to decreased type I IFN signaling and immunosuppression.

Identification of SARS-CoV2-mediated suppression of NRF2 signaling reveals a potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

The paper identifies NRF2 agonists 4-OI and DMF as inhibitors of SARS-CoV2 replication and inflammatory responses, effective against multiple viruses.

Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation

The paper shows that ZBP1 sensing of endogenous nucleic acids causes necroptosis and skin inflammation in RIPK1-deficient keratinocytes, linked to IL-17 immune responses.

SAMHD1 limits the efficacy of forodesine in leukaemia by protecting cells against cytotoxicity of dGTP

This paper shows that SAMHD1 protects cells from dGTP toxicity caused by forodesine, and that forodesine can selectively kill SAMHD1-deficient leukemia cells.

Varicella-Zoster Virus ORF9 Is an Antagonist of the DNA Sensor cGAS

This study identifies ORF9 as a VZV protein that inhibits the cGAS/STING pathway, reducing type I IFN production during infection.

Type-1 IFN primed monocytes in pathogenesis of idiopathic pulmonary fibrosis

The paper identifies type-1 IFN-primed monocytes as key drivers of fibrosis in IPF, showing their increased levels, altered phenotype, and potential as therapeutic targets.

cGAMP loading enhances the immunogenicity of VLP vaccines

This study shows that incorporating cGAMP into virus-like particles (VLPs) enhances their immunogenicity, leading to stronger T cell responses and antibody titres against HIV and influenza viruses.

Hypoxia induces transcriptional and translational downregulation of the type I interferon (IFN) pathway in multiple cancer cell types

This study shows hypoxia reduces type I IFN pathway activity in cancer cells through transcriptional and chromatin changes, independent of HIF1/2.