Phosphodiesterase-5 inhibition inhibits epithelial ATP release and restores detrusor contractility in rats with type 2 diabetes via an increase in bladder blood flow
T. Kabuto, S. Inamura, H. Kobayashi, X. Zha, K. Nagase, M. Taga, M. Seki, N. Tanaka, Y. Okumura, O. Yokoyama, N. Terada
This study shows that PDE-5 inhibition improves bladder function in T2DM rats by increasing blood flow, reducing ATP release, and modulating inflammatory and growth factor markers.
bioRxiv · Mar 26, 2024 · PreprintPharmacology & Toxicology