N. Tanaka

A beta-Galactosidase acting on unique galactosides: the structure and function of a beta-1,2-galactosidase from Bacteroides xylanisolvens, an intestinal bacterium

This study identifies a beta-galactosidase from Bacteroides xylanisolvens that hydrolyzes beta-1,2-galactooligosaccharides, revealing its unique substrate specificity through structural and biochemical analysis.

Phosphodiesterase-5 inhibition inhibits epithelial ATP release and restores detrusor contractility in rats with type 2 diabetes via an increase in bladder blood flow

This study shows that PDE-5 inhibition improves bladder function in T2DM rats by increasing blood flow, reducing ATP release, and modulating inflammatory and growth factor markers.

Extensive distribution of β-1,2-glucanases: finding of new glycoside hydrolase families of β-1,2-glucanases

The paper identifies three new glycoside hydrolase families of β-1,2-glucanases and reveals their functional and structural relationships within a superfamily.

Functional and structural analysis of a cyclization domain in a cyclic beta-1,2-glucan synthase

The paper functionally and structurally analyzes the cyclization domain of a cyclic β-1,2-glucan synthase, revealing it produces cyclic β-1,2-glucans through transglycosylation without hydrolysis and proposes it belongs to a new glycoside hydrolase family.

Essential role of an acidic endosomal environment in JAK3-mediated signal transduction

This study shows that acidic endosomal environments are essential for JAK3-mediated signal transduction and that IAVNs like chloroquine and monensin disrupt this process, affecting cytokine signaling and arthritis.

The stability of NPM1 oligomers regulated by acidic disordered regions controls the quality of liquid droplets

This study shows that NPM1 oligomer stability, regulated by acidic disordered regions, determines liquid droplet quality through molecular dynamics and mutant analyses.

Transcriptional regulation of sphingolipid metabolism in budding yeast

This study identifies Com2 as a master transcriptional regulator of sphingolipid metabolism in yeast, showing it upregulates Ypk1 expression to control sphingolipid biosynthesis and response to environmental stress.

Developing a Biomimetic Evaluation Method for Antiviral Coatings Using Artificial Saliva Droplets.

The paper develops a biomimetic method using artificial saliva droplets to evaluate antiviral coatings by simulating real-world viral transmission conditions.

Effect of belt electrode-skeletal muscle electrical stimulation on immobilization-induced muscle fibrosis

This study investigates how belt electrode-skeletal muscle electrical stimulation (B-SES) affects immobilization-induced muscle fibrosis by reducing macrophage accumulation and fibrotic markers in rats.