Author

T. Kandola

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

J. J. Lange· 2 shared J. R. Unruh· 2 shared J. Wu· 2 shared M. Cook· 2 shared S. Venkatesan· 2 shared A. Box· 1 shared A. C. Box· 1 shared A. Rodriguez Gama· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBiophysics

J. J. Lange

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2 papers

Recent·Most cited

Pathologic polyglutamine aggregation begins with a self-poisoning polymer crystal

T. Kandola, S. Venkatesan, J. Zhang, B. T. Lerbakken, A. Von Schulze, J. F. Blanck, J. Wu, J. R. Unruh, P. Berry, J. J. Lange, A. C. Box, M. Cook, C. Sagui, Randal Halfmann

This study identifies the structural basis of polyglutamine nucleation, showing that a four-stranded steric zipper initiates aggregation and poisons further growth.

bioRxiv · Aug 29, 2021Biophysics

Quantifying nucleation in vivo reveals the physical basis of prion-like phase behavior

T. Khan, T. Kandola, J. Wu, E. Ketter, S. Venkatesan, J. J. Lange, A. Rodriguez Gama, A. Box, J. R. Unruh, M. Cook, R. Halfmann

The paper quantifies nucleation in living cells using DAmFRET and shows that kinetic barriers influence prion-like phase behavior and protein aggregation.

bioRxiv · Apr 19, 2018Biophysics