Author

J. J. Lange

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Cell Biology· 3 Evolutionary Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:cell signaling & trafficking· 7 Assay:proteomics· 5 Research Focus:chromatin & epigenetic regulation· 3 Organism:yeast· 3 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

R. Halfmann· 5 shared A. Rodriguez Gama· 3 shared J. R. Unruh· 3 shared J. Wu· 3 shared M. Cook· 3 shared S. E. Zanders· 3 shared S. Venkatesan· 3 shared J. Unruh· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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5 shared papersBiophysics

R. Halfmann

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Author profile →

10 papers

Recent·Most cited

Adaptor protein supersaturation drives innate immune signaling and cell fate

A. Rodriguez Gama, T. Miller, S. Venkatesan, J. J. Lange, J. Wu, X. Song, W. D. Bradford, M. Cook, J. R. Unruh, R. Halfmann

The paper identifies DFD adaptors as energy reservoirs through supersaturation, showing their role in innate immune signaling and cell fate decisions.

bioRxiv · Mar 20, 2023 · PreprintBiophysics

Serial Capture Affinity Purification and Integrated Structural Modeling of the H3K4me3 Binding and DNA Damage Related WDR76:SPIN1 Complex

X. Liu, Y. Zhang, Z. Wen, Y. Hao, C. Banks, J. J. Lange, J. Cesare, S. Bhattacharya, B. Slaughter, J. Unruh, L. Florens, J. Workman, M. Washburn

The paper uses SCAP to isolate the WDR76:SPIN1 complex, identifies H3K4me3 binding, and shows its role in DNA damage response through structural modeling and interaction network analysis.

bioRxiv · Jan 31, 2023Biochemistry

The wtf meiotic driver gene family has unexpectedly persisted for over 100 million years

M. De Carvalho, G.-S. Jia, A. Nidamangala Srinivasa, R. B. Billmyre, Y.-H. Xu, J. J. Lange, I. M. Sabbarini, L.-L. Du, S. E. Zanders

This study identifies the persistence of the wtf meiotic driver gene family across four fission yeast species diverging over 100 million years ago, showing that active meiotic drive systems can persist long-term.

bioRxiv · Jun 24, 2022Evolutionary Biology

A nucleation barrier spring-loads the CBM signalosome for binary activation

A. Rodriguez Gama, T. Miller, J. J. Lange, J. Unruh, R. Halfmann

The paper investigates the CBM signalosome's binary activation mechanism, showing that BCL10's nucleation barrier stores energy for rapid NF-κB activation upon stimulation.

bioRxiv · Jan 28, 2022Cell Biology

Pathologic polyglutamine aggregation begins with a self-poisoning polymer crystal

T. Kandola, S. Venkatesan, J. Zhang, B. T. Lerbakken, A. Von Schulze, J. F. Blanck, J. Wu, J. R. Unruh, P. Berry, J. J. Lange, A. C. Box, M. Cook, C. Sagui, Randal Halfmann

This study identifies the structural basis of polyglutamine nucleation, showing that a four-stranded steric zipper initiates aggregation and poisons further growth.

bioRxiv · Aug 29, 2021Biophysics

Diverse mating phenotypes impact the spread of wtf meiotic drivers in S. pombe

S. E. Zanders, J. F. Lopez Hernandez, R. M. Helston, J. J. Lange, R. B. Billmyre, S. H. Schaffner, M. T. Eickbush, S. McCroskey

The paper examines mating phenotypes in S. pombe natural isolates to explain the prevalence of meiotic drivers despite low outcrossing rates.

bioRxiv · May 28, 2021Evolutionary Biology

Mechanistic inferences from analysis of measurements of protein phase transitions in live cells

A. E. Posey, K. M. Ruff, J. M. Lalmansingh, T. S. Kandola, J. J. Lange, R. Halfmann, R. V. Pappu

This paper develops a supervised method to classify phase transitions in live cells using DAmFRET data, revealing sequence features that drive prion-like behavior and enabling quantitative analysis of nucleation probabilities.

bioRxiv · Nov 4, 2020Biophysics

The wtf4 meiotic driver utilizes controlled protein aggregation to generate selective cell death

N. L. Nuckolls, A. C. Mok, J. J. Lange, K. Yi, T. S. Kandola, A. M. Hunn, S. McCroskey, J. L. Snyder, M. A. Bravo Nunez, M. McClain, S. A. McKinney, C. Wood, R. Halfmann, S. E. Zanders

This study shows that the wtf4 meiotic driver uses protein aggregation and sequestration to selectively kill cells, revealing a mechanism for meiotic drive.

bioRxiv · Feb 5, 2020Cell Biology

Quantifying nucleation in vivo reveals the physical basis of prion-like phase behavior

T. Khan, T. Kandola, J. Wu, E. Ketter, S. Venkatesan, J. J. Lange, A. Rodriguez Gama, A. Box, J. R. Unruh, M. Cook, R. Halfmann

The paper quantifies nucleation in living cells using DAmFRET and shows that kinetic barriers influence prion-like phase behavior and protein aggregation.

bioRxiv · Apr 19, 2018Biophysics

NECAPs are negative regulators of the AP2 clathrin adaptor complex

G. M. Beacham, E. A. Partlow, J. J. Lange, G. Hollopeter

The paper identifies NECAPs as negative regulators of the AP2 clathrin adaptor complex by promoting its closed, inactive conformation and inactivating it late in endocytosis.

bioRxiv · Sep 22, 2017Cell Biology