Author

A. C. Box

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Evolutionary Biology· 1 Zoology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:flow cytometry· 1

Frequent Co-Authors

N. Rohner· 2 shared R. Peuss· 2 shared A. Accorsi· 1 shared A. Kenzior· 1 shared A. Sanchez Alvarado· 1 shared A. Von Schulze· 1 shared B. P. Slaughter· 1 shared B. T. Lerbakken· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersZoology

N. Rohner

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Pathologic polyglutamine aggregation begins with a self-poisoning polymer crystal

T. Kandola, S. Venkatesan, J. Zhang, B. T. Lerbakken, A. Von Schulze, J. F. Blanck, J. Wu, J. R. Unruh, P. Berry, J. J. Lange, A. C. Box, M. Cook, C. Sagui, Randal Halfmann

This study identifies the structural basis of polyglutamine nucleation, showing that a four-stranded steric zipper initiates aggregation and poisons further growth.

bioRxiv · Aug 29, 2021Biophysics

Image3C: a multimodal image-based and label independent integrative method for single-cell analysis

A. Accorsi, A. C. Box, R. Peuss, C. Wood, A. Sanchez Alvarado, N. Rohner

Image3C enables single-cell analysis without species-specific reagents by using image-based clustering and CNN integration to detect cellular composition changes.

bioRxiv · Dec 15, 2020Zoology

Adaptation to low parasite abundance affects immune investment strategy and immunopathological responses of cavefish

R. Peuss, A. C. Box, S. Chen, Y. Wang, D. Tsuchiya, J. L. Persons, A. Kenzior, E. Maldonado, J. Krishnan, J. P. Scharsack, B. P. Slaughter, N. Rohner

This study shows that cavefish, adapted to low parasite abundance, have a more sensitive immune system with reduced proinflammatory responses and shifted immune investment to adaptive immunity.

bioRxiv · Dec 18, 2019Evolutionary Biology