Author

J. R. Unruh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Organism:yeast· 3 Research Focus:development & morphogenesis· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

J. J. Lange· 3 shared J. Wu· 3 shared M. Cook· 3 shared S. L. Jaspersen· 3 shared S. Venkatesan· 3 shared A. Rodriguez Gama· 2 shared R. Halfmann· 2 shared S. E. Smith· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersBiophysics

J. J. Lange

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Author profile →

7 papers

Recent·Most cited

Adaptor protein supersaturation drives innate immune signaling and cell fate

A. Rodriguez Gama, T. Miller, S. Venkatesan, J. J. Lange, J. Wu, X. Song, W. D. Bradford, M. Cook, J. R. Unruh, R. Halfmann

The paper identifies DFD adaptors as energy reservoirs through supersaturation, showing their role in innate immune signaling and cell fate decisions.

bioRxiv · Mar 20, 2023 · PreprintBiophysics

Distinct states of nucleolar stress induced by anti-cancer drugs

T. A. Potapova, J. R. Unruh, J. J. Conkright-Fincham, C. A. S. Banks, L. Florens, D. A. Schneider, J. L. Gerton

This study identifies distinct nucleolar stress states induced by various anticancer drugs and characterizes their molecular and morphological effects.

bioRxiv · Nov 18, 2022 · PreprintCell Biology

Pathologic polyglutamine aggregation begins with a self-poisoning polymer crystal

T. Kandola, S. Venkatesan, J. Zhang, B. T. Lerbakken, A. Von Schulze, J. F. Blanck, J. Wu, J. R. Unruh, P. Berry, J. J. Lange, A. C. Box, M. Cook, C. Sagui, Randal Halfmann

This study identifies the structural basis of polyglutamine nucleation, showing that a four-stranded steric zipper initiates aggregation and poisons further growth.

bioRxiv · Aug 29, 2021Biophysics

A distinct inner nuclear membrane proteome in Saccharomyces cerevisiae gametes

S. N. Shelton, S. E. Smith, J. R. Unruh, S. L. Jaspersen

The paper identifies a distinct inner nuclear membrane proteome in yeast gametes, showing unique gene expression and protein composition compared to mitotic cells.

bioRxiv · Aug 2, 2021Cell Biology

Redistribution of centrosomal proteins by centromeres and Polo kinase controls partial nuclear envelope breakdown in fission yeast

A. J. Bestul, Z. Yu, J. R. Unruh, S. L. Jaspersen

The paper shows that centromere linkage to the SPB drives redistribution of Sad1 and Plo1 activation, facilitating partial NEBD and spindle formation in fission yeast.

bioRxiv · Dec 1, 2020Cell Biology

Membrane insertion function for SUN-KASH complex revealed by high resolution analysis of yeast centrosomes

J. Chen, J. M. Gardner, Z. Yu, S. E. Smith, S. McKinney, B. D. Slaughter, J. R. Unruh, S. L. Jaspersen

The paper uses high-resolution imaging to reveal the structure and function of the SUN-KASH complex in yeast centrosome insertion, identifying Mps3 as a fifth SPIN component and a novel LINC complex.

bioRxiv · Sep 10, 2018Cell Biology

Quantifying nucleation in vivo reveals the physical basis of prion-like phase behavior

T. Khan, T. Kandola, J. Wu, E. Ketter, S. Venkatesan, J. J. Lange, A. Rodriguez Gama, A. Box, J. R. Unruh, M. Cook, R. Halfmann

The paper quantifies nucleation in living cells using DAmFRET and shows that kinetic barriers influence prion-like phase behavior and protein aggregation.

bioRxiv · Apr 19, 2018Biophysics