Author

T. L. Koch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:comparative / phylogenetic analysis· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

H. Safavi-Hemami· 3 shared B. M. Olivera· 2 shared E. Engholm· 2 shared I. B. L. Ramiro· 2 shared K. Chase· 2 shared K. J. Jensen· 2 shared W. E. Bjorn-Yoshimoto· 2 shared A. Patwardhan· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersEvolutionary Biology

H. Safavi-Hemami

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Author profile →

3 papers

Recent·Most cited

Venom-inspired somatostatin receptor 4 (SSTR4) agonists as new drug leads for peripheral pain conditions

W. E. Bjorn-Yoshimoto, I. B. L. Ramiro, T. L. Koch, E. Engholm, H. Y. Yeung, K. K. Sorensen, C. M. Goddard, K. L. Jensen, N. A. A. Smith, L. F. Martin, B. J. Smith, K. L. Madsen, K. J. Jensen, A. Patwardhan, H. Safavi-Hemami

This study identifies venom-derived SSTR4 agonists as potential non-opioid therapeutics for peripheral pain conditions.

bioRxiv · Apr 29, 2024 · PreprintPharmacology & Toxicology

Discovery of Novel Bilaterian Signaling Peptides Using Cone Snail Toxins

T. L. Koch, J. P. Torres, R. P. Baskin, P. F. Salcedo, K. Chase, B. M. Olivera, H. Safavi-Hemami

The paper uses cone snail toxins to discover novel bilaterian signaling peptides by comparing them to sequences from model organisms.

bioRxiv · Aug 5, 2022 · PreprintEvolutionary Biology

Reconstructing the Origins of a Neuropeptide Signaling System Using the Accelerated Evolution of Biodiverse Cone Snail Venoms

T. L. Koch, I. B. L. Ramiro, P. Florez-Salcedo, E. Engholm, K. J. Jensen, K. Chase, B. M. Olivera, W. E. Bjorn-Yoshimoto, H. Safavi-Hemami

The paper identifies SSRP-like signaling genes in mollusks and other protostomes, showing their evolutionary origin and divergence into venom peptides in cone snails.

bioRxiv · Nov 5, 2021 · PreprintEvolutionary Biology