Author

K. L. Madsen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:dimensionality reduction· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

M. D. Lycas· 3 shared N. R. Christensen· 3 shared U. Gether· 3 shared A. T. Soerensen· 2 shared F. Herborg· 2 shared G. Noes-Holt· 2 shared J. H. Schmidt· 2 shared J. Rombach· 2 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCell Biology

M. D. Lycas

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Membrane curvature association of amphipathic helix 8 drives constitutive GPCR endocytosis

R. Herlo, J. H. Schmidt, J. Rombach, A. H. Larsen, M. Stoklund, M. Perslev, T. T. E. Nielsen, K. A. Andersen, C. Herenbrink, M. D. Lycas, A. Ejdrup, N. Christensen, J. P. Christensen, M. Salman, F. Herborg, , k. L. Madsen

The paper identifies amphipathic helix 8 as a driver of constitutive GPCR endocytosis through membrane curvature association.

bioRxiv · Mar 27, 2024Cell Biology

mPD5, a peripherally restricted PICK1 inhibitor for treating chronic pain

K. L. Jensen, N. R. Christensen, C. M. Goddard, S. E. Jager, I. B. Kanneworff, A. Jakobsen, G. Noes-Holt, L. Jimenez-Fernandez, E. G. Peck, L. Sivertsen, R. C. Baro, G. A. Houser, F. P. Mayer, M. D. del Castillo, M. L. Topp, , K. L. Madsen

This paper develops mPD5, a peripherally restricted PICK1 inhibitor that reduces chronic pain and associated symptoms in mice without significant side effects.

bioRxiv · Mar 3, 2023 · PreprintPharmacology & Toxicology

Relative enrichment - a density-based colocalization measure for single-molecule localization microscopy

A. L. Ejdrup, M. D. Lycas, N. Lorenzen, A. Konomi, F. Herborg, K. L. Madsen, U. Gether

The paper introduces a density-based colocalization measure for SMLM data, demonstrating its application on simulated and neuronal data.

bioRxiv · Feb 8, 2022 · PreprintCell Biology

Bi-directional protein-protein interactions control liquid-liquid phase separation of PSD-95 and its interaction partners

N. R. Christensen, C. P. Pedersen, V. Sereikaite, J. N. Pedersen, M. Vistrup-Parry, A. T. Soerensen, D. E. Otzen, L. Arleth, K. Teilum, K. L. Madsen, K. Stromgaard

This study identifies the minimal peptide responsible for stargazin-mediated LLPS of PSD-95 and shows that pharmacological inhibitors can promote LLPS formation.

bioRxiv · Mar 3, 2021Biochemistry

Coding variants identified in diabetic patients alter PICK1 BAR domain function in insulin granule biogenesis

R. C. Andersen, M. D. Lycas, J. H. Schmidt, N. R. Christensen, V. K. Lund, J. Rombach, M. Stoklund, D. Stapleton, G. Noes-Holt, M. P. Keller, A. M. Jansen, R. Herlo, O. Kjaerulff, B. Holst, A. D. Attie, , k. L. Madsen

The paper identifies coding variants in PICK1 that impair its BAR domain function, leading to altered insulin granule biogenesis in diabetic patients.

bioRxiv · Oct 5, 2020Cell Biology