Author

T. M. Lowe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:deep learning· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

A. Bagi· 1 shared A. C. Manning· 1 shared A. Manning· 1 shared A. R. Jimenez· 1 shared B. D. Laurent· 1 shared G. Li· 1 shared H. Li· 1 shared H. Moore· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCell Biology

A. Bagi

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Author profile →

3 papers

Recent·Most cited

Gammaherpesvirus infection triggers the formation of tRNA fragments from premature tRNAs

A. C. Manning, M. M. Bashir, A. R. Jimenez, H. Upton, K. Collins, T. M. Lowe, J. M. Tucker

This study shows that gammaherpesvirus infection leads to tRNA cleavage, producing tRNA fragments that are regulated by tRNA splicing factors and essential for viral replication.

mBio · Jul 9, 2025Peer-reviewedMicrobiology

tRNA Methylation Resolves Codon Usage Bias at the Limit of Cell Viability

I. Masuda, Y. Yamaki, R. Detroja, S. Tagore, H. Moore, S. Maharjan, Y. Nakano, T. Christian, R. Matsubara, T. M. Lowe, M. Frenkel-Morgenstern, Y.-M. Hou

This study shows that m1G37 tRNA modification neutralizes differential proline codon decoding, and its absence requires a minor isoacceptor for E. coli viability.

bioRxiv · May 14, 2022Microbiology

Distinct stress-dependent signatures of cellular and extracellular tRNA-derived small RNAs (tDRs)

G. Li, A. Manning, A. Bagi, X. Yang, J. Howard, P. P. Chan, T. Sweeney, H. Li, B. D. Laurent, M. I. Kontaridis, L. C. Laurent, K. V. K. Jensen, S. F. Aranki, J. D. Muehlschlegel, R. Kitchen, , S. Das

The paper identifies distinct extracellular tRNA-derived small RNA (tDR) fragmentation signatures associated with different stress responses and shows their potential as biomarkers in human disease.

bioRxiv · Sep 3, 2021Cell Biology