Author

Y.-M. Hou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 2 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:protein folding & dynamics· 3 Organism:E. coli· 2 Organism:human· 2 Assay:protein structure· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

H. Gamper· 4 shared T. Christian· 4 shared I. Masuda· 3 shared S. Maharjan· 3 shared M. Wanunu· 2 shared Y. Yamaki· 2 shared A. B. Conn· 1 shared A. Buskirk· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersBiochemistry

H. Gamper

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Post-Transcriptional Methylation of Mitochondrial-tRNA Differentially Contributes to Mitochondrial Pathology

S. Maharjan, H. Gamper, Y. Yamaki, R. Y. Henley, N. Sheng, T. Suzuki, T. Suzuki, J. A. Piccirilli, M. Wanunu, E. Seifert, D. C. Wallace, Y.-M. Hou

The paper shows that N1-methylation at position 9 of mt-Leu(UAA) stabilizes wild-type mt-tRNA but destabilizes pathogenic variants, suggesting methylation control could be therapeutic.

bioRxiv · Dec 9, 2023Cell Biology

Nucleolar Essential Protein 1 (Nep1): Elucidation of Enzymatic Catalysis Mechanism by Combined Molecular Dynamics Simulation and Quantum Chemical Calculations

M. Jedrzejewski, B. Belza, I. Lewandowska, M. Sadlej, A. P. Perlinska, R. Augustyniak, T. Christian, Y.-M. Hou, M. Kalek, J. I. Sulkowska

This study elucidates the catalytic mechanism of Nep1 using molecular dynamics and quantum chemical calculations, revealing that water mediates proton transfer rather than a conserved serine residue.

bioRxiv · Mar 21, 2023 · PreprintBiophysics

Synthesis of Long RNA with a Site-Specific Modification by Enzymatic Splint Ligation

H. Gamper, C. McCormick, S. Tavakoli, M. Wanunu, S. H. Rouhanifard, Y.-M. Hou

This paper improves the synthesis of long RNA with site-specific modifications using enzymatic splint ligation by addressing structural and sequence heterogeneity.

bioRxiv · Sep 17, 2022 · PreprintBiochemistry

tRNA Methylation Resolves Codon Usage Bias at the Limit of Cell Viability

I. Masuda, Y. Yamaki, R. Detroja, S. Tagore, H. Moore, S. Maharjan, Y. Nakano, T. Christian, R. Matsubara, T. M. Lowe, M. Frenkel-Morgenstern, Y.-M. Hou

This study shows that m1G37 tRNA modification neutralizes differential proline codon decoding, and its absence requires a minor isoacceptor for E. coli viability.

bioRxiv · May 14, 2022Microbiology

Loss of N1-methylation of G37 in tRNA induces ribosome stalling and reprograms gene expression

I. Masuda, J.-Y. Hwang, T. Christian, S. Maharjan, F. Mohammad, H. Gamper, A. Buskirk, Y.-M. Hou

This study shows that loss of N1-methylation of G37 in tRNA causes ribosome stalling and alters gene expression, resembling the stringent response.

bioRxiv · May 27, 2021Microbiology

Insights into Genome Recoding from the Mechanism of a Classic +1-Frameshifting tRNA

H. Gamper, H. Li, I. Masuda, D. M. Robkis, T. Christian, A. B. Conn, g. Blaha, E. J. Petersson, R. L. Gonzalez, Y.-M. Hou

This study elucidates the mechanism of +1-frameshifting by tRNA SufB2, showing it uses triplet-slippage and ribosome conformational changes to decode quadruplet codons for genome recoding.

bioRxiv · Dec 31, 2020Biochemistry