Y. Nakano

Development of a high throughput system to screen compounds that revert the activated hepatic stellate cells to a quiescent-like state

The paper develops a high throughput system to screen compounds that revert activated hepatic stellate cells to a quiescent-like state, showing that a single compound can induce deactivation.

Analysis of chronic host-aspergilloma interactions using a novel mouse model

This paper develops a novel mouse model of aspergilloma to study host-fungal interactions, revealing Th1/Th17 responses and angiogenesis induced by dead fungal hyphae.

tRNA Methylation Resolves Codon Usage Bias at the Limit of Cell Viability

This study shows that m1G37 tRNA modification neutralizes differential proline codon decoding, and its absence requires a minor isoacceptor for E. coli viability.

Phylogenetic trees of closely related bacterial species and subspecies based on frequencies of short nucleotide sequences

This study constructs phylogenetic trees of bacterial species using pentanucleotide frequency analysis and introduces an R tool, Phy5, for genome-wide comparisons.

Targeted single-cell genomics reveals novel host adaptation strategies of the symbiotic bacteria Endozoicomonas in Acropora tenuis coral

This study uses single-cell genomics to analyze Endozoicomonas bacteria in Acropora tenuis corals, revealing host-adaptive genes that may enhance coral stress tolerance.

Involvement of I-BAR protein IRSp53 in tumor cell growth via extracellular microvesicle secretion

This study shows IRSp53 promotes tumor cell proliferation through microvesicle secretion, as evidenced by reduced secretion and phosphorylation in knockout cells and increased survival in IRSp53-deficient mice.

NPC1L1 inhibition disturbs lipid trafficking and induces large lipid droplet formation in intestinal absorptive epithelial cells

This study shows that NPC1L1 inhibition reduces chylomicron assembly and secretion in intestinal cells by limiting cholesterol availability, leading to large lipid droplet formation.

Proximity proteomics identifies cancer cell membrane cis-molecular complex as a potential cancer target

The paper identifies cancer cell membrane cis-molecular complexes (BiCATs) as potential targets using proximity proteomics and shows their utility in combination drug strategies.