Author

T. M. Smith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1 Paleontology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

C. S. Pepperell· 3 shared L. L. Bohr· 2 shared M. A. Youngblom· 2 shared M. B. O'Neill· 2 shared T. D. Mortimer· 2 shared B. M. Willardson· 1 shared C. Austin· 1 shared D. F. Mosher· 1 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersMicrobiology

C. S. Pepperell

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Adaptation of the Mycobacterium tuberculosis transcriptome to biofilm growth

M. A. Youngblom, T. M. Smith, C. S. Pepperell

This study characterizes the transcriptomic adaptation of Mycobacterium tuberculosis to biofilm growth, revealing strain-specific regulatory systems and the role of non-coding RNA in facilitating rapid environmental responses.

bioRxiv · Jul 18, 2023 · PreprintMicrobiology

Oxygen isotopes in orangutan teeth reveal recent and ancient climate variation

T. M. Smith, M. Arora, C. Austin, J. N. Avila, M. Duval, T. T. Lim, P. Piper, P. Vaiglova, J. d. Vos, I. S. Williams, J.-x. Zhao, D. R. Green

This paper uses oxygen isotopes in orangutan teeth to reconstruct recent and ancient rainfall patterns, revealing environmental changes in Borneo and Sumatra.

bioRxiv · Jul 18, 2023 · PreprintPaleontology

Visualizing the chaperone-mediated folding trajectory of the G protein β5 β-propeller

S. Wang, M. I. Sass, Y. Kwon, W. G. Ludlam, T. M. Smith, E. J. Carter, N. E. Gladden, M. Riggi, J. H. Iwasa, B. M. Willardson, P. S. Shen

This study visualizes the chaperone-mediated folding trajectory of Gβ5 using cryo-EM, showing how CCT stabilizes intermediates to fold the β-propeller domain.

bioRxiv · May 4, 2023Biochemistry

Rapid adaptation of a complex trait during experimental evolution of Mycobacterium tuberculosis

T. M. Smith, M. A. Youngblom, J. F. Kernien, M. A. Mohamed, S. S. Fry, L. L. Bohr, T. D. Mortimer, M. B. O'Neill, C. S. Pepperell

This study uses experimental evolution of Mycobacterium tuberculosis to identify genetic loci associated with biofilm formation and shows that regulatory mutations rapidly adapt under selective pressure.

bioRxiv · Apr 8, 2021Microbiology

Adaptation in a fibronectin binding autolysin of Staphylococcus saprophyticus

T. D. Mortimer, D. S. Annis, M. B. O'Neill, L. L. Bohr, T. M. Smith, H. N. Poinar, D. F. Mosher, C. S. Pepperell

The paper identifies a mutation in the aas gene of Staphylococcus saprophyticus that may enhance its ability to colonize the urinary tract, contributing to its pathogenicity.

bioRxiv · Nov 10, 2017Microbiology