T. M. Zikry

Cell cycle plasticity underlies fractional resistance to palbociclib in ER+/HER2- breast tumor cells

This study identifies cell cycle plasticity as a mechanism for fractional resistance to palbociclib in ER+/HER2- breast tumor cells using single-cell imaging and computational analysis.

The structure of the human cell cycle

The paper uses single-cell imaging and manifold learning to reveal alternative cell cycle paths and mechanisms of exit and re-entry in human cells.