Author

J. C. Limas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Organism:human· 2 Assay:imaging· 2 Approach:microscopy & imaging analysis· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

J. G. Cook· 4 shared K. M. Kedziora· 4 shared J. E. Purvis· 3 shared C. D. Taylor· 2 shared C. L. Young· 2 shared H. K. Sobon· 2 shared S. R. Taylor· 2 shared W. Stallaert· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersCell Biology

J. G. Cook

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4 papers

Recent·Most cited

The molecular architecture of cell cycle arrest

W. Stallaert, S. R. Taylor, K. M. Kedziora, M. S. Johnson, C. D. Taylor, H. K. Sobon, C. L. Young, J. C. Limas, J. Varblow Holloway, J. G. Cook, J. E. Purvis

This study maps the molecular architecture of cell cycle arrest by analyzing 49 effectors, identifying stress-specific arrest states and mechanisms, and showing convergence onto a senescent state with a G1-like signature.

bioRxiv · Apr 27, 2022Cell Biology

Quantitative Profiling of Adaptation to Cyclin E Overproduction

J. C. Limas, A. N. Littlejohn, A. M. House, K. M. Kedziora, B. L. Mouery, B. Ma, D. Fleifel, A. Walens, M. M. Aleman, D. Dominguez, J. G. Cook

This study examines how mammalian cells adapt to chronic cyclin E overproduction, revealing that adaptation involves downregulation of G1-regulated genes and partial resistance to replication stress.

bioRxiv · Jul 26, 2021Cell Biology

The structure of the human cell cycle

W. Stallaert, K. M. Kedziora, C. D. Taylor, T. M. Zikry, H. K. Sobon, S. R. Taylor, C. L. Young, J. C. Limas, J. G. Cook, J. E. Purvis

The paper uses single-cell imaging and manifold learning to reveal alternative cell cycle paths and mechanisms of exit and re-entry in human cells.

bioRxiv · Feb 11, 2021Cell Biology

Precise detection of S phase onset reveals decoupled G1/S transition events

G. D. Grant, K. M. Kedziora, J. C. Limas, J. E. Purvis, J. G. Cook

The paper introduces PIP-FUCCI, a new reporter system for precise detection of S phase onset, revealing that APCCdh1 inactivation is not strictly required for S phase entry.

bioRxiv · Apr 12, 2018Cell Biology