W. Stallaert

αKG-mediated carnitine synthesis promotes homologous recombination via histone acetylation

This study shows that αKG-mediated carnitine synthesis supports HR proficiency by promoting histone acetylation, which enhances DNA repair.

The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming

This study shows that chemotherapy-induced senescence-associated secretome promotes metastasis in ovarian cancer by reprogramming metabolism and increasing cell detachment.

Spatial molecular profiling of mixed invasive ductal-lobular breast cancers reveals heterogeneity in intrinsic molecular subtypes, oncogenic signatures, and mutations

This study uses spatial molecular profiling to show that mixed invasive ductal-lobular breast cancers have distinct molecular subtypes, oncogenic signatures, and mutations in different tumor regions, leading to prognostic uncertainty and therapeutic challenges.

The molecular architecture of cell cycle arrest

This study maps the molecular architecture of cell cycle arrest by analyzing 49 effectors, identifying stress-specific arrest states and mechanisms, and showing convergence onto a senescent state with a G1-like signature.

Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2

This study identifies cyclin F as a regulator of p130/RBL2 degradation via SCF, showing its role in cell cycle control and potential implications in cancer.

The structure of the human cell cycle

The paper uses single-cell imaging and manifold learning to reveal alternative cell cycle paths and mechanisms of exit and re-entry in human cells.

Contact inhibitory Eph signaling suppresses EGF-promoted cell migration by decoupling EGFR activity from vesicular recycling

The paper shows Eph receptor signaling alters EGFR vesicular trafficking to suppress migratory Akt signaling while preserving proliferative ERK signaling during EGF stimulation.