Leishmania mexicana Centrin Knock out Parasites Promote M1-polarizing Metabolic Changes
G. Volpedo, T. Oljuskin, N. Azodi, S. Hamano, G. Matlashewski, S. Gannavaram, H. Nakhasi, A. R. Satoskar
This study shows that Leishmania mexicana centrin knockout parasites induce M1-polarizing metabolic changes through enhanced pentose phosphate pathway activity, promoting pro-inflammatory responses.
bioRxiv · Sep 16, 2022 · PreprintMicrobiology