Author

A. R. Satoskar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 5 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Assay:metabolomics· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

S. Gannavaram· 5 shared H. Nakhasi· 4 shared G. Matlashewski· 3 shared G. Volpedo· 3 shared S. Hamano· 3 shared N. Azodi· 2 shared N. Ismail· 2 shared P. Bhattacharya· 2 shared

Activity by Year

2021-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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5 shared papersImmunology

S. Gannavaram

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Leishmania mexicana Centrin Knock out Parasites Promote M1-polarizing Metabolic Changes

G. Volpedo, T. Oljuskin, N. Azodi, S. Hamano, G. Matlashewski, S. Gannavaram, H. Nakhasi, A. R. Satoskar

This study shows that Leishmania mexicana centrin knockout parasites induce M1-polarizing metabolic changes through enhanced pentose phosphate pathway activity, promoting pro-inflammatory responses.

bioRxiv · Sep 16, 2022 · PreprintMicrobiology

Leishmania mexicana Promotes Pain-reducing Metabolomic Reprogramming In Cutaneous Lesions

G. Volpedo, T. Oljuskin, B. Cox, Y. Mercado, C. Askwith, N. Azodi, S. Gannavaram, H. Nakhasi, A. R. Satoskar

This study identifies anti-nociceptive metabolic pathways upregulated in Leishmania mexicana infection, including purines and endocannabinoids, which may explain the painless nature of cutaneous leishmaniasis lesions.

bioRxiv · Aug 9, 2022 · PreprintMicrobiology

Dual scRNA-Seq analysis reveals rare and uncommon parasitized cell populations in chronic L. donovani infection

K. Karagiannis, S. Gannavaram, C. Verma, P. Bhattacharya, H. Nakhasi, A. R. Satoskar

This study uses dual scRNA-seq to identify rare parasitized cell populations in L. donovani infection, revealing HSCs as dominant in bone marrow and new infected cell types in spleen.

bioRxiv · Jul 26, 2022Immunology

Centrin-deficient Leishmania mexicana confers protection against Old World visceral leishmaniasis

S. Karmakar, G. Volpedo, W.-W. Zhang, P. Lypaczewski, N. Ismail, L. F. Oliveira, J. Oristian, C. Meneses, S. Gannavaram, S. Kamhawi, S. Hamano, J. G. Valenzuela, R. DEY, A. R. Satoskar, G. Matlashewski, H. Nakhasi

This study shows that centrin-deficient L. mexicana parasites protect against Old World visceral leishmaniasis in a hamster model by reducing parasite burden and altering cytokine responses.

bioRxiv · Jun 27, 2022Immunology

Skin resident memory cells generated by the L. major centrin gene deleted parasites mediate protective immune response analogous to leishmanization

N. Ismail, S. Karmakar, P. Bhattacharya, T. Sepahpour, K. Takeda, S. Hamano, G. Matlashewski, A. R. Satoskar, S. Gannavaram, R. DEY, H. L. Nakhasi

This study shows that a genetically modified Leishmania vaccine generates skin-resident memory T cells that provide protection similar to leishmanization.

bioRxiv · Dec 17, 2021 · PreprintImmunology