S. Gannavaram

Leishmania mexicana Centrin Knock out Parasites Promote M1-polarizing Metabolic Changes

This study shows that Leishmania mexicana centrin knockout parasites induce M1-polarizing metabolic changes through enhanced pentose phosphate pathway activity, promoting pro-inflammatory responses.

Leishmania mexicana Promotes Pain-reducing Metabolomic Reprogramming In Cutaneous Lesions

This study identifies anti-nociceptive metabolic pathways upregulated in Leishmania mexicana infection, including purines and endocannabinoids, which may explain the painless nature of cutaneous leishmaniasis lesions.

Dual scRNA-Seq analysis reveals rare and uncommon parasitized cell populations in chronic L. donovani infection

This study uses dual scRNA-seq to identify rare parasitized cell populations in L. donovani infection, revealing HSCs as dominant in bone marrow and new infected cell types in spleen.

Centrin-deficient Leishmania mexicana confers protection against Old World visceral leishmaniasis

This study shows that centrin-deficient L. mexicana parasites protect against Old World visceral leishmaniasis in a hamster model by reducing parasite burden and altering cytokine responses.

Skin resident memory cells generated by the L. major centrin gene deleted parasites mediate protective immune response analogous to leishmanization

This study shows that a genetically modified Leishmania vaccine generates skin-resident memory T cells that provide protection similar to leishmanization.

Preclinical validation of a second generation leishmanization vaccine against vector transmitted fatal visceral leishmaniasis

This study evaluates the protective efficacy of a CRISPR-edited Leishmania major strain against visceral leishmaniasis in hamsters and shows it induces a pro-inflammatory immune response and prevents disease.

A Second Generation Leishmanization Vaccine with a Markerless Attenuated Leishmania major Strain using CRISPR gene editing

This paper describes a CRISPR-edited Leishmania major strain for a second-generation leishmanization vaccine that is marker-free and safe, showing protection in mice comparable to traditional leishmanization.