Author

G. Volpedo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:metabolomics· 2 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1

Frequent Co-Authors

S. Gannavaram· 5 shared G. Matlashewski· 4 shared S. Hamano· 4 shared A. R. Satoskar· 3 shared C. Meneses· 3 shared H. Nakhasi· 3 shared J. G. Valenzuela· 3 shared J. Oristian· 3 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersMicrobiology

S. Gannavaram

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Leishmania mexicana Centrin Knock out Parasites Promote M1-polarizing Metabolic Changes

G. Volpedo, T. Oljuskin, N. Azodi, S. Hamano, G. Matlashewski, S. Gannavaram, H. Nakhasi, A. R. Satoskar

This study shows that Leishmania mexicana centrin knockout parasites induce M1-polarizing metabolic changes through enhanced pentose phosphate pathway activity, promoting pro-inflammatory responses.

bioRxiv · Sep 16, 2022 · PreprintMicrobiology

Leishmania mexicana Promotes Pain-reducing Metabolomic Reprogramming In Cutaneous Lesions

G. Volpedo, T. Oljuskin, B. Cox, Y. Mercado, C. Askwith, N. Azodi, S. Gannavaram, H. Nakhasi, A. R. Satoskar

This study identifies anti-nociceptive metabolic pathways upregulated in Leishmania mexicana infection, including purines and endocannabinoids, which may explain the painless nature of cutaneous leishmaniasis lesions.

bioRxiv · Aug 9, 2022 · PreprintMicrobiology

Centrin-deficient Leishmania mexicana confers protection against Old World visceral leishmaniasis

S. Karmakar, G. Volpedo, W.-W. Zhang, P. Lypaczewski, N. Ismail, L. F. Oliveira, J. Oristian, C. Meneses, S. Gannavaram, S. Kamhawi, S. Hamano, J. G. Valenzuela, R. DEY, A. R. Satoskar, G. Matlashewski, H. Nakhasi

This study shows that centrin-deficient L. mexicana parasites protect against Old World visceral leishmaniasis in a hamster model by reducing parasite burden and altering cytokine responses.

bioRxiv · Jun 27, 2022Immunology

Preclinical validation of a second generation leishmanization vaccine against vector transmitted fatal visceral leishmaniasis

H. L. Nakhasi, R. DEY, S. Gannavaram, S. Karmakar, P. Bhattacharya, N. Ismail, A. Satoskar, G. Volpedo, L. F. Oliveira, J. Oristian, C. Meneses, J. G. Valenzuela, S. Kamhawi, W. W. Zhang, G. Matlashewski, , K. Pandey

This study evaluates the protective efficacy of a CRISPR-edited Leishmania major strain against visceral leishmaniasis in hamsters and shows it induces a pro-inflammatory immune response and prevents disease.

bioRxiv · Nov 18, 2020Immunology

A Second Generation Leishmanization Vaccine with a Markerless Attenuated Leishmania major Strain using CRISPR gene editing

W. W. Zhang, S. Karmakar, S. Gannavaram, R. Dey, P. Lypaczewski, N. Ismail, A. Siddiqui, V. Simonyan, F. Oliveira, I. V. Coutinho-Abreu, T. DeSouza-Vieira, C. Meneses, J. Oristian, T. D. Serfim, A. Musa, , H. L. Nakhasi

This paper describes a CRISPR-edited Leishmania major strain for a second-generation leishmanization vaccine that is marker-free and safe, showing protection in mice comparable to traditional leishmanization.

bioRxiv · May 4, 2020Microbiology