Interdependent allosteric FFA2R modulators synergistically induce functional selective activation and desensitization in neutrophils
S. Lind, A. Holdfeldt, J. Martensson, M. Sundqvist, T. P. Kenakin, L. Bjorkman, H. Forsman, C. Dahlgren
The paper shows two non-activating FFA2R allosteric modulators synergistically activate neutrophil NADPH-oxidase without triggering Ca2+ signaling.
bioRxiv · Oct 17, 2019Pharmacology & Toxicology