A. Holdfeldt

Structural determinants in the Staphylococcus aureus derived phenol-soluble modulin-α2 peptide required for neutrophil formyl peptide receptor activation

This study identifies structural features of PSM2 that determine its selectivity for FPR1 and FPR2 and its biased signaling properties.

Multiple ligand recognition sites in free fatty acid receptor 2 (FFAR2) direct distinct neutrophil activation patterns

The paper identifies two distinct allosteric modulators of FFAR2 that trigger different neutrophil activation patterns through separate binding sites.

Barbadin selectively modulates FPR2-mediated neutrophil functions independent of receptor endocytosis

This study shows Barbadin enhances FPR2-mediated ROS production in neutrophils without affecting receptor endocytosis, suggesting AP2 plays a role in ROS release.

Interdependent allosteric FFA2R modulators synergistically induce functional selective activation and desensitization in neutrophils

The paper shows two non-activating FFA2R allosteric modulators synergistically activate neutrophil NADPH-oxidase without triggering Ca2+ signaling.

The putative Gαq-inhibiting pepducin P4Pal10 distinctly modulates function of the Gαi-coupled receptors FPR2 and FFA2R in neutrophils

The paper shows that P4Pal10, a Gαq-inhibiting pepducin, modulates FPR2 and FFA2R signaling in neutrophils independently of Gq pathways.

Allosteric receptor modulation of FFA2R turns natural agonists into potent activators of the superoxide generating neutrophil NADPH-oxidase

The paper shows that an allosteric modulator enhances acetate's ability to activate neutrophil NADPH-oxidase, increasing reactive oxygen species production.