M. Sundqvist

The ketone body acetoacetate activates human neutrophils through FFA2R

This study shows that acetoacetate activates human neutrophils via FFA2R, affecting cAMP levels, calcium signaling, ROS production, and migration.

THE ALLOSTERICALLY MODULATED FREE FATTY ACID RECEPTOR 2 IS TRANSACTIVATED BY AN INCREASE IN THE CYTOSOLIC CONCENTRATION OF CALCIUM IONS

The paper shows that P2Y2R signals, via Gq and increased [Ca2+]i, transactivate allosterically modulated FFA2R, revealing a unique cross-talk mechanism between GPCRs.

Structural determinants in the Staphylococcus aureus derived phenol-soluble modulin-α2 peptide required for neutrophil formyl peptide receptor activation

This study identifies structural features of PSM2 that determine its selectivity for FPR1 and FPR2 and its biased signaling properties.

The two formyl peptide receptors differently regulate GPR84-mediated neutrophil NADPH-oxidase activity

This study shows that FPR1 and FPR2 differentially regulate GPR84-mediated neutrophil NADPH-oxidase activity, with FPR2 reactivation amplifying ROS production and FPR1 suppressing it.

Barbadin selectively modulates FPR2-mediated neutrophil functions independent of receptor endocytosis

This study shows Barbadin enhances FPR2-mediated ROS production in neutrophils without affecting receptor endocytosis, suggesting AP2 plays a role in ROS release.

Core-2 O-glycans are required for Galectin-3 interaction with the osteoarthritis related protein lubricin

The paper shows that core-2 O-glycans are necessary for galectin-3 to bind lubricin, and this interaction is reduced in late-stage osteoarthritis.

Interdependent allosteric FFA2R modulators synergistically induce functional selective activation and desensitization in neutrophils

The paper shows two non-activating FFA2R allosteric modulators synergistically activate neutrophil NADPH-oxidase without triggering Ca2+ signaling.

Functional and signaling characterization of the neutrophil FPR2 selective agonist Act-389949

This study characterizes Act-389949, a FPR2 agonist, showing it induces neutrophil signaling and chemotaxis comparable to WKYMVM, with increased stability against oxidation.

Allosteric receptor modulation of FFA2R turns natural agonists into potent activators of the superoxide generating neutrophil NADPH-oxidase

The paper shows that an allosteric modulator enhances acetate's ability to activate neutrophil NADPH-oxidase, increasing reactive oxygen species production.