J. Martensson

The ketone body acetoacetate activates human neutrophils through FFA2R

This study shows that acetoacetate activates human neutrophils via FFA2R, affecting cAMP levels, calcium signaling, ROS production, and migration.

The two formyl peptide receptors differently regulate GPR84-mediated neutrophil NADPH-oxidase activity

This study shows that FPR1 and FPR2 differentially regulate GPR84-mediated neutrophil NADPH-oxidase activity, with FPR2 reactivation amplifying ROS production and FPR1 suppressing it.

Multiple ligand recognition sites in free fatty acid receptor 2 (FFAR2) direct distinct neutrophil activation patterns

The paper identifies two distinct allosteric modulators of FFAR2 that trigger different neutrophil activation patterns through separate binding sites.

Interdependent allosteric FFA2R modulators synergistically induce functional selective activation and desensitization in neutrophils

The paper shows two non-activating FFA2R allosteric modulators synergistically activate neutrophil NADPH-oxidase without triggering Ca2+ signaling.

Allosteric receptor modulation of FFA2R turns natural agonists into potent activators of the superoxide generating neutrophil NADPH-oxidase

The paper shows that an allosteric modulator enhances acetate's ability to activate neutrophil NADPH-oxidase, increasing reactive oxygen species production.