Author

T. R. Walsh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:E. coli· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

C. MacLean· 2 shared L. Ogunlana· 2 shared P. K. Jangir· 2 shared Q. Yang· 2 shared C. Pal· 1 shared E. J. Stevens· 1 shared J. D. Caballero· 1 shared L. P. Shaw· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersEvolutionary Biology

C. MacLean

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2 papers

Recent·Most cited

Pre-existing chromosomal polymorphisms in pathogenic E. coli potentiate the evolution of antibiotic resistance by MCR-1 plasmid acquisition

P. K. Jangir, Q. Yang, L. P. Shaw, J. D. Caballero, L. Ogunlana, R. M. Wheatley, T. R. Walsh, C. MacLean

The paper shows pre-existing lpxC polymorphisms in E. coli enhance the evolution of colistin resistance via MCR-1 plasmid acquisition through positive epistasis.

bioRxiv · Feb 20, 2022 · PreprintEvolutionary Biology

The evolution of colistin resistance increases bacterial resistance to host antimicrobial peptides and virulence

P. K. Jangir, L. Ogunlana, P. Szili, M. Czikkely, E. J. Stevens, Y. Yang, Q. Yang, Y. Wang, C. Pal, T. R. Walsh, C. MacLean

This study shows that colistin resistance in E. coli increases resistance to host antimicrobial peptides and virulence, highlighting risks of therapeutic AMP use.

bioRxiv · Feb 12, 2022Microbiology