T. S. Jorgensen

A treasure trove of 1,034 actinomycete genomes

The paper provides over 1,000 high-quality Actinomycetia genomes, revealing genomic structures and biosynthetic gene cluster organization with ecological and biotechnological implications.

Biosynthesis of the azoxy compound azodyrecin from Streptomyces mirabilis P8-A2

This study identifies and characterizes the biosynthetic pathway for azodyrecin, an azoxy compound produced by Streptomyces mirabilis P8-A2, revealing key enzymes and gene cluster distribution across Streptomyces species.

Identification of the 216kbp gene cluster and structure elucidation of gargantulides B and C, new complex 52-membered macrolides from Amycolatopsis sp.

This study identifies a 216 kbp gene cluster and elucidates the structures of gargantulides B and C, new 52-membered macrolides from Amycolatopsis sp., revealing their biosynthetic pathway and antibacterial activity.

Characterization and Engineering of Streptomyces griseofuscus DSM 40191 as a Potential Host for Heterologous Expression of Biosynthetic Gene Clusters

This paper characterizes Streptomyces griseofuscus DSM 40191 as a potential heterologous host for biosynthetic gene clusters and demonstrates its ability to produce secondary metabolites.

CRISPR-nRAGE, a Cas9 nickase-reverse transcriptase assisted versatile genetic engineering toolkit for E. coli

CRISPR-nRAGE enables DSB-free, single-nucleotide resolution genome editing in E. coli by combining Cas9 nickase and reverse transcriptase, allowing substitutions, deletions, and insertions.

Genomic and chemical diversity of Bacillus subtilis secondary metabolites against plant pathogenic fungi

This study examines the genomic and chemical diversity of secondary metabolites in Bacillus subtilis strains to understand their biocontrol properties against plant pathogenic fungi.

Distribution of Epsilon-Polylysine Synthetases in Coryneform Bacteria Isolated from Cheese and Human Skin

The paper identifies epsilon-polylysine synthetase genes in coryneform bacteria from cheese and human skin, suggesting natural production of epsilon-polylysine in these environments.