Y. Tong

An infection and pathogenesis mouse model of SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR)

This study establishes a mouse model using GX_P2V(short_3UTR) to evaluate drug and vaccine efficacy against SARS-CoV-2.

Mining the biosynthetic landscape of lactic acid bacteria unearths a new family of RiPPs assembled by a novel type of ThiF-like adenylyltransferases

The paper identifies a new family of RiPPs in lactic acid bacteria biosynthetic gene clusters, revealing a novel adenylyltransferase mechanism for macrocyclic imide formation.

Virtual Growing Child (VGC): A general normative comparative system via quantitative dynamic MRI for quantifying pediatric regional respiratory anomalies with application in thoracic insufficiency syndrome (TIS)

The paper introduces VGC, a normative database for pediatric respiratory measurements using MRI, to quantify regional respiratory anomalies in thoracic insufficiency syndrome patients.

Divergent lineage trajectories and genetic landscapes in human gastric intestinal metaplasia organoids associated with early neoplastic progression

An interpretable integration model improving disease-free survival prediction for gastric cancer based on CT images and clinical parameters

This paper proposes a model integrating deep features, radiomics features, and clinical parameters to improve gastric cancer disease-free survival prediction, achieving a 3%-5% C-index and 10% AUC improvement.

Targeted NAD+ Delivery for Intimal Hyperplasia and Re-endothelialization: A Novel Anti-restenotic Therapy Approach

This study demonstrates that targeted NAD+ delivery via nanocarriers reduces intimal hyperplasia and promotes endothelial regeneration in a rat model of restenosis.

INHBA/Activin A promotes tumor growth and induces resistance to anti-PD-L1 therapy by suppressing IFN-γ signaling

This study shows that INHBA/activin A suppresses IFN-γ signaling, leading to resistance to anti-PD-L1 therapy and promoting tumor growth.

Assessment of the macrovascular contribution to resting-state fMRI functional connectivity at 3 Tesla

This study assesses the macrovascular contribution to resting-state fMRI functional connectivity, finding strong correlations between large veins and arteries and demonstrating their significant impact on whole-GM connectivity.

Identification and characterization of a beta-1,4 Galactosidase from Elizabethkingia meningoseptica and its application on living cell surface

This study identifies and characterizes a beta-1,4 galactosidase from Elizabethkingia meningoseptica that can remove galactose from living cell surfaces, named geGalaseI.

Real-time Quantification of in vivo cerebrospinal fluid velocity using fMRI inflow effect

This paper develops a method to estimate real-time CSF flow velocity using fMRI inflow effect, showing nonlinear relationships and validating it in human volunteers.

High-resolution structure of mouse radial spoke and its in-situ structure in ependymal cilia revealed by cryo-EM and cryo-ET

The paper presents high-resolution cryo-EM structures of mouse radial spokes and cryo-ET maps of ependymal cilia, revealing structural features and mutations linked to ciliary disorders.

PENet: A phenotype encoding network for automatic extraction and representation of morphological discriminative features

PENet is a deep learning model that automatically extracts and encodes morphological features into hash codes, showing effectiveness in feature extraction and image retrieval across beetle datasets.

Functional divergences of natural variations of TaNAM-A1 controlling leaf senescence initiation during wheat grain filling

This study identifies TaNAM-A1 as a key gene regulating leaf senescence and grain yield in wheat, showing functional differences among its haplotypes.

Epigenetic modifications mediate cultivar-specific root development and metabolic adaptation to nitrogen availability in wheat

Caltubin regulates microtubule stability via Ca2+-dependent mechanisms favouring neurite regrowth

This study shows caltubin enhances neurite regrowth in neurons by stabilizing microtubules through Ca2+-dependent mechanisms.

Inhibitory effects of GT0918 on acute lung injury and the molecular mechanisms of anti-inflammatory response

This study shows GT0918 reduces cytokine release and inflammation in COVID-19 by inhibiting NF-κB and activating NRF2, suggesting its potential for treating both mild and severe cases.

Pathogen-Host Adhesion between SARS-CoV-2 S Proteins from Different Variants and Human ACE2 Probed at Single-Molecule and Single-Cell Levels

This study investigates the adhesion of SARS-CoV-2 S proteins from different variants to human ACE2 using single-molecule and single-cell force spectroscopy, finding Delta variant has the highest binding affinity.

Suppression of tumor/host intrinsic CMTM6 drives anti-tumor cytotoxicity in a PD-L1 independent manner

This study shows that suppressing CMTM6 in tumors or hosts enhances anti-tumor immunity independently of PD-L1, suggesting CMTM6 as a target for gene therapy.

Single-nucleus RNA Sequencing and Spatial Transcriptomics Reveal the Immunological Microenvironment of Cervical Squamous Cell Carcinoma

This study uses snRNA-seq and Stereo-seq to analyze the immunological microenvironment of cervical squamous cell carcinoma, identifying immune cell clusters and their associations with tumor progression and patient survival.

Structural and functional characterization of ubiquitin variant inhibitors for the JAMM-family deubiquitinases STAMBP and STAMBPL1

This paper develops Ub variant inhibitors for JAMM-family DUBs STAMBP and STAMBPL1, showing high affinity and selectivity, with structural insights and improved potency over existing inhibitors.

Implicit Laplacian of Enhanced Edge: An Unguided Algorithm for Accurate and Automated Quantitative Analysis of Cytoskeletal Images

The paper introduces ILEE, an unguided algorithm for accurate and automated quantitative analysis of cytoskeletal images, resolving limitations of existing methods and enabling novel feature measurements.

The PD-L1 and TLR7 dual-targeting nanobody-drug conjugate exerts potent antitumor efficacy by orchestrating innate and adaptive immune responses

The paper develops a PD-L1 and TLR7 dual-targeting nanobody-drug conjugate that synergistically activates innate and adaptive immune responses, showing potent antitumor effects in both 'hot' and 'cold' tumors.

The Coxiella burnetii QpH1 plasmid is a virulence factor for colonizing bone marrow-derived murine macrophages

This study shows that the QpH1 plasmid in Coxiella burnetii is essential for colonizing murine macrophages and highlights its role in the bacterium's persistence in rodents.

Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry

The paper identifies species-specific genetic differences in ACE2 that determine SARS-CoV-2 entry capability and shows that humanizing these residues in koala and mouse ACE2 enables viral entry.

The wheat cytosolic glutamine synthetase GS1.1 modulates N assimilation and spike development by characterizing CRISPR-edited mutants

This study identifies TaGS1.1 as critical for nitrogen assimilation and spike development in wheat by analyzing CRISPR-edited mutants and their growth responses under varying nitrogen conditions.

CRISPR-nRAGE, a Cas9 nickase-reverse transcriptase assisted versatile genetic engineering toolkit for E. coli

CRISPR-nRAGE enables DSB-free, single-nucleotide resolution genome editing in E. coli by combining Cas9 nickase and reverse transcriptase, allowing substitutions, deletions, and insertions.

Novel and potent inhibitors targeting DHODH, a rate-limiting enzyme in de novo pyrimidine biosynthesis, are broad-spectrum antiviral against RNA viruses including newly emerged coronavirus SARS-CoV-2

This paper identifies two potent DHODH inhibitors with broad-spectrum antiviral activity against RNA viruses, including SARS-CoV-2, and suggests their potential clinical use.

Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p

This study shows berberine reverses multidrug resistance in Candida albicans by hijacking the Mdr1p efflux pump for drug import, leading to mitochondrial dysfunction and selective cell death.

A single nonsynonymous mutation on gene encoding E protein of Zika virus leads to increased neurovirulence in vivo

Engineering oleaginous yeast Yarrowia lipolytica for violacein production: extraction, quantitative measurement and culture optimization

This paper optimizes violacein extraction and culture conditions in Yarrowia lipolytica to improve yield and purity, establishing a scalable production platform.